Acetylation of BmAtg8 inhibits starvation-induced autophagy initiation
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03513-y
Abstract: Silkworm (Bombyx mori) is not only a model organism for scientific studies, but also a commercial insect for agricultural production. BmAtg8 (a B. mori homolog of yeast Atg8) plays crucial roles in macroautophagy (hereafter referred… read more here.
Keywords: acetylation bmatg8; autophagy initiation; bmatg8; starvation induced ... See more keywords
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.01.027
Abstract: Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the… read more here.
Keywords: tbk1; atg13 fip200; autophagy initiation; syntaxin ... See more keywords
The mammalian ULK1 complex and autophagy initiation
Sign Up to like & getrecommendations! Published in 2017 at "Essays in Biochemistry"
DOI: 10.1042/ebc20170021
Abstract: Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the… read more here.
Keywords: complex autophagy; autophagy initiation; ulk1; ulk1 complex ... See more keywords
New functions of a known autophagy regulator: VCP and autophagy initiation
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1905974
Abstract: ABSTRACT VCP, a conserved ATPase, is involved in several cellular processes, and mutations in this protein are associated with various diseases. VCP also plays a role in autophagosome maturation. However, because a deficiency in autophagosome… read more here.
Keywords: new functions; autophagy initiation; vcp autophagy; functions known ... See more keywords
Deacetylation of ATG4B promotes autophagy initiation under starvation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo0412
Abstract: Eukaryotes initiate autophagy when facing environmental changes such as a lack of external nutrients. However, the mechanisms of autophagy initiation are still not fully elucidated. Here, we showed that deacetylation of ATG4B plays a key… read more here.
Keywords: deacetylation atg4b; starvation deacetylation; starvation; autophagy initiation ... See more keywords
Compound 275# Induces Mitochondria-Mediated Apoptosis and Autophagy Initiation in Colorectal Cancer Cells through an Accumulation of Intracellular ROS
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28073211
Abstract: Colorectal cancer (CRC) is the most common intestinal malignancy, and nearly 70% of patients with this cancer develop metastatic disease. In the present study, we synthesized a novel compound, termed N-(3-(5,7-dimethylbenzo [d]oxazol-2-yl)phenyl)-5-nitrofuran-2-carboxamide (compound 275#), and… read more here.
Keywords: compound 275; apoptosis; autophagy initiation; apoptosis autophagy ... See more keywords