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   Articles with "autophagy initiation" as a keyword



The autophagy initiation factor ATG13 mRNA is stabilized by the RNA‐binding protein YBX3

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recommendations! Published in 2024 at "Febs Letters"

DOI: 10.1002/1873-3468.15035

Abstract: Autophagy, a highly conserved form of cellular recycling, is essential for cellular homeostasis. Its dysregulation has been linked to neurodegenerative diseases and various cancers, including breast cancer. We set out to determine if the RNA‐binding… read more here.

Keywords: ybx3; binding protein; initiation factor; autophagy initiation ... See more keywords

Acetylation of BmAtg8 inhibits starvation-induced autophagy initiation

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recommendations! Published in 2019 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-019-03513-y

Abstract: Silkworm (Bombyx mori) is not only a model organism for scientific studies, but also a commercial insect for agricultural production. BmAtg8 (a B. mori homolog of yeast Atg8) plays crucial roles in macroautophagy (hereafter referred… read more here.

Keywords: acetylation bmatg8; autophagy initiation; bmatg8; starvation induced ... See more keywords

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.

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recommendations! Published in 2019 at "Developmental cell"

DOI: 10.1016/j.devcel.2019.01.027

Abstract: Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the… read more here.

Keywords: tbk1; atg13 fip200; autophagy initiation; syntaxin ... See more keywords

The mammalian ULK1 complex and autophagy initiation

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recommendations! Published in 2017 at "Essays in Biochemistry"

DOI: 10.1042/ebc20170021

Abstract: Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the… read more here.

Keywords: complex autophagy; autophagy initiation; ulk1; ulk1 complex ... See more keywords
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New functions of a known autophagy regulator: VCP and autophagy initiation

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recommendations! Published in 2021 at "Autophagy"

DOI: 10.1080/15548627.2021.1905974

Abstract: ABSTRACT VCP, a conserved ATPase, is involved in several cellular processes, and mutations in this protein are associated with various diseases. VCP also plays a role in autophagosome maturation. However, because a deficiency in autophagosome… read more here.

Keywords: new functions; autophagy initiation; vcp autophagy; functions known ... See more keywords

TRIM22 functions as a scaffold protein for autophagy initiation

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recommendations! Published in 2025 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2025.2498926

Abstract: ABSTRACT Tripartite motif (TRIM) family proteins are increasingly recognized as important regulators of autophagy under various physiological and pathological conditions. TRIM22 has been previously shown to mediate autophagosome-lysosome fusion, but its potential role in earlier… read more here.

Keywords: stages autophagy; scaffold protein; trim22; class iii ... See more keywords

Deacetylation of ATG4B promotes autophagy initiation under starvation

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abo0412

Abstract: Eukaryotes initiate autophagy when facing environmental changes such as a lack of external nutrients. However, the mechanisms of autophagy initiation are still not fully elucidated. Here, we showed that deacetylation of ATG4B plays a key… read more here.

Keywords: deacetylation atg4b; starvation deacetylation; starvation; autophagy initiation ... See more keywords

Molecular Mechanisms Underlying Initiation and Activation of Autophagy

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recommendations! Published in 2024 at "Biomolecules"

DOI: 10.3390/biom14121517

Abstract: Autophagy is an important catabolic process to maintain cellular homeostasis and antagonize cellular stresses. The initiation and activation are two of the most important aspects of the autophagic process. This review focuses on mechanisms underlying… read more here.

Keywords: initiation; mechanisms underlying; activation autophagy; activation ... See more keywords

Compound 275# Induces Mitochondria-Mediated Apoptosis and Autophagy Initiation in Colorectal Cancer Cells through an Accumulation of Intracellular ROS

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recommendations! Published in 2023 at "Molecules"

DOI: 10.3390/molecules28073211

Abstract: Colorectal cancer (CRC) is the most common intestinal malignancy, and nearly 70% of patients with this cancer develop metastatic disease. In the present study, we synthesized a novel compound, termed N-(3-(5,7-dimethylbenzo [d]oxazol-2-yl)phenyl)-5-nitrofuran-2-carboxamide (compound 275#), and… read more here.

Keywords: compound 275; apoptosis; autophagy initiation; apoptosis autophagy ... See more keywords