YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23105
Abstract: Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the… read more here.
Keywords: biogenesis; autophagy lysosomal; yy1 cooperates; biogenesis melanoma ... See more keywords
Next-Generation Sequencing Approaches to Define the Role of the Autophagy Lysosomal Pathway in Human Disease: The Example of LysoPlex.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6934-0_15
Abstract: Next-Generation Sequencing (NGS) technologies have deeply changed the throughput of genetic testing allowing analyzing millions of DNA fragments in parallel. One key application is the understanding of genetically heterogeneous and complex diseases where 50-100 different… read more here.
Keywords: autophagy lysosomal; sequencing approaches; pathway; next generation ... See more keywords
Research progress on the effect of autophagy-lysosomal pathway on tumor drug resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111925
Abstract: Autophagy is an intracellular degradation pathway that is highly conserved during the evolution of eukaryotes and is based on lysosome. Under nutritional deficiencies or stress, cells can clear damaged and necrotic organelles and proteins through… read more here.
Keywords: drug resistance; lysosomal pathway; autophagy lysosomal; pathway tumor ... See more keywords
Atherosclerosis: Trehalose induces macrophage autophagy–lysosomal biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cardiology"
DOI: 10.1038/nrcardio.2017.97
Abstract: autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat. Comms. 8, 15750 (2017) The development of atherosclerotic plaques is characterized by progressive macrophage autophagy–lysosomal dysfunction. According to a new study by Sergin et al. published in… read more here.
Keywords: autophagy lysosomal; atherosclerosis; macrophage; lysosomal biogenesis ... See more keywords
Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20211288
Abstract: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson's disease (PD), for which the LRRK2 locus itself represents a risk factor. Idiopathic and LRRK2-related PD share… read more here.
Keywords: lrrk2 mutants; lysosomal pathway; parkinson disease; lrrk2 ... See more keywords
ATM loss disrupts the autophagy-lysosomal pathway
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1805860
Abstract: ABSTRACT ATM (ataxia telangiectasia mutated) protein is found associated with multiple organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with ATR (ataxia telangiectasia and Rad3 related). Mutation of the ATM gene results in… read more here.
Keywords: protein; kinase; autophagy lysosomal; ataxia telangiectasia ... See more keywords
Role of c-Abl-GSK3&bgr; Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy155
Abstract: Impairment in autophagy-lysosomal pathway (ALP) results in accumulation of misfolded proteins and dysfunctional organelles, which is the hallmark of neurodegenerative diseases including Parkinson's disease (PD). Recent studies revealed activated nonreceptor tyrosine kinase Abelson (c-Abl) in… read more here.
Keywords: mpp induced; abl gsk3; autophagy lysosomal; gsk3 ... See more keywords
Free fatty acid exacerbates diabetic kidney injury by suppressing autophagy-lysosomal function via ER stress
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733227
Abstract: Diabetic kidney disease (DKD), the leading cause of chronic kidney disease, is characterized by accumulation of renal tubule free fatty acids (FFAs) and triglyceride (TG)-enriched lipid droplets (LDs) and cell death. The present study aimed… read more here.
Keywords: cell; lysosomal function; kidney; physiology ... See more keywords
Exendin-4 Attenuates Hepatic Steatosis by Promoting the Autophagy-Lysosomal Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/4246086
Abstract: Dysregulated hepatic steatosis may lead to chronic liver inflammation and nonalcoholic steatohepatitis (NASH). Recent studies have suggested that exendin-4, a glucagon-like peptide-1 agonist, may be a promising therapeutic for hepatic steatosis and NASH. However, the… read more here.
Keywords: lysosomal pathway; steatosis; hepatic steatosis; exendin ... See more keywords
Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.602574
Abstract: Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has been demonstrated to alleviate non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism has not been fully elucidated. Increasing evidence suggests that autophagy is involved in the… read more here.
Keywords: hepatic steatosis; autophagy lysosomal; treatment; liraglutide ... See more keywords
c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.844297
Abstract: Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. NPA patients present severe and progressive neurodegeneration starting at an early age. Currently, there is… read more here.
Keywords: pick type; disease; abl activation; niemann pick ... See more keywords