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   Articles with "autophagy lysosome" as a keyword



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Association study of genetic variation in the autophagy lysosome pathway genes and risk of eight kinds of cancers

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recommendations! Published in 2018 at "International Journal of Cancer"

DOI: 10.1002/ijc.31288

Abstract: The autophagy lysosome pathway is essential to maintain cell viability and homeostasis in response to many stressful environments, which is reported to play a vital role in cancer development and therapy. However, the association of… read more here.

Keywords: kinds cancers; autophagy lysosome; lysosome pathway; cancer ... See more keywords
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UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.27860

Abstract: Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions during DNA virus infections have been extensively documented. However, its homeostatic regulation is not well understood. Our study demonstrates that Unc‐93… read more here.

Keywords: autophagy lysosome; unc93b1 attenuates; cgas sting; degradation ... See more keywords
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Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.04.088

Abstract: The most prominent hallmarks of many neurodegenerative diseases are the accumulation of misfolded protein aggregates and the death of certain neuronal populations. Autophagy is the major intracellular mechanism that degrades protein aggregates and damaged cellular… read more here.

Keywords: mek5; mtor; lysosome pathway; autophagy lysosome ... See more keywords
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AKT modulates the autophagy-lysosome pathway via TFEB

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recommendations! Published in 2017 at "Cell Cycle"

DOI: 10.1080/15384101.2017.1337968

Abstract: The serine and threonine kinase AKT (also known as protein kinase B, PKB) integrates inputs from growth factors and metabolic effectors to control key multifunctional signaling hubs via direct phosphorylation of substrates that control cell… read more here.

Keywords: akt; activity; lysosome pathway; autophagy lysosome ... See more keywords
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Retromer regulates the lysosomal clearance of MAPT/tau

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recommendations! Published in 2020 at "Autophagy"

DOI: 10.1080/15548627.2020.1821545

Abstract: ABSTRACT The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset… read more here.

Keywords: mapt tau; aggregation; retromer; clearance ... See more keywords
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C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.

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recommendations! Published in 2021 at "Autophagy"

DOI: 10.1080/15548627.2021.1872189

Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically distinct classes of neurodegenerative disorders. Yet, they share a range of genetic, cellular, and molecular features. Hexanucleotide repeat expansions (HREs) in the C9orf72 gene… read more here.

Keywords: kinase; repeat; c9orf72; als ftd ... See more keywords
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Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response.

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recommendations! Published in 2021 at "Autophagy"

DOI: 10.1080/15548627.2021.1896906

Abstract: The autophagy-lysosome system is an important cellular degradation pathway that recycles dysfunctional organelles and cytotoxic protein aggregates. A decline in this system is pathogenic in many human diseases including neurodegenerative disorders, fatty liver disease, and… read more here.

Keywords: system; autophagy lysosome; grade lysosomal; low grade ... See more keywords
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Graphene Oxide Nanocolloids Induce Autophagy-Lysosome Dysfunction in Mouse Embryonic Stem Cells.

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recommendations! Published in 2019 at "Journal of biomedical nanotechnology"

DOI: 10.1166/jbn.2019.2684

Abstract: In this study, we aimed to investigate the in vitro impacts and mechanisms of graphene oxide (GO) nanocolloids on autophagy in mouse embryonic stem cells (mESCs). Our results showed that GO nanocolloids treatment induced autophagosome… read more here.

Keywords: graphene oxide; oxide nanocolloids; mouse embryonic; embryonic stem ... See more keywords
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Coronavirus Usurps the Autophagy-Lysosome Pathway and Induces Membranes Rearrangement for Infection and Pathogenesis

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recommendations! Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.846543

Abstract: Autophagy is a crucial and conserved homeostatic mechanism for early defense against viral infections. Recent studies indicate that coronaviruses (CoVs) have evolved various strategies to evade the autophagy–lysosome pathway. In this minireview, we describe the… read more here.

Keywords: autophagy lysosome; membrane vesicles; double membrane; lysosome pathway ... See more keywords
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Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23031131

Abstract: Rab21 is a GTPase protein that is functional in intracellular trafficking and involved in the pathologies of many diseases, such as Alzheimer’s disease (AD), glioma, cancer, etc. Our previous work has reported its interaction with… read more here.

Keywords: rab21 protein; autophagy lysosome; lysosome pathway; pathway ... See more keywords
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Spring Viremia of Carp Virus N Protein Negatively Regulates IFN Induction through Autophagy-Lysosome-Dependent Degradation of STING.

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recommendations! Published in 2022 at "Journal of immunology"

DOI: 10.4049/jimmunol.2200477

Abstract: Fish possess a powerful IFN system to defend against aquatic virus infections. Nevertheless, spring viremia of carp virus (SVCV) causes large-scale mortality in common carp and significant economic losses to aquaculture. Therefore, it is necessary… read more here.

Keywords: autophagy lysosome; virus; lysosome dependent; carp ... See more keywords