Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107837
Abstract: Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases. One of the least understood components of the autophagy… read more here.
Keywords: autophagy machinery; structure; structure human; human atg9a ... See more keywords
Recent advances in autophagic machinery: a proteomic perspective
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2020.1808464
Abstract: ABSTRACT Introduction Autophagy is an evolutionarily conserved cellular clearance process, by which cytosolic components are delivered to autolysosomes for breakdown and recycling to maintain cellular homeostasis. During the past decades, autophagy has been found to… read more here.
Keywords: autophagic machinery; advances autophagic; machinery; autophagy machinery ... See more keywords
Phosphoregulation of the autophagy machinery by kinases and phosphatases.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1909407
Abstract: Eukaryotic cells use post-translational modifications to diversify and dynamically coordinate the function and properties of protein networks within various cellular processes. For example, the process of autophagy strongly depends on the balanced action of kinases… read more here.
Keywords: kinases phosphatases; phosphoregulation autophagy; autophagy machinery;
The role of host autophagy machinery in controlling Toxoplasma infection
Sign Up to like & getrecommendations! Published in 2019 at "Virulence"
DOI: 10.1080/21505594.2018.1518102
Abstract: ABSTRACT Toxoplasma gondii is an obligate intracellular parasitic protist that infects a wide range of warm-blooded vertebrates. Although this parasite can cause serious complications, infections are often asymptomatic, allowing T. gondii to persist in its… read more here.
Keywords: role host; infection; host; autophagy machinery ... See more keywords
Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aaz7714
Abstract: Reconstituting autophagosome nucleation To stay healthy, our cells must constantly dispose of harmful material. Autophagy, or self-eating, is an important mechanism to ensure the clearance of bulky material. Such material is enwrapped by cellular membranes… read more here.
Keywords: machinery; autophagy machinery; formation; atg9 vesicles ... See more keywords
A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009017
Abstract: TRIM5α is a key cross-species barrier to retroviral infection, with certain TRIM5 alleles conferring increased risk of HIV-1 infection in humans. TRIM5α is best known as a species-specific restriction factor that directly inhibits the viral… read more here.
Keywords: trim5; autophagy machinery; canonical role; non canonical ... See more keywords
The Emerging Role of Extracellular Vesicles and Autophagy Machinery in NASH—Future Horizons in NASH Management
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012185
Abstract: Non-alcoholic fatty liver disease (NAFLD) is considered the most frequent chronic hepatic disease in the general population, while it is the first cause of liver transplantation in the US. NAFLD patients will subsequently develop non-alcoholic… read more here.
Keywords: autophagy machinery; disease; nash management; extracellular vesicles ... See more keywords
Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogen
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.37476
Abstract: During plant cell invasion, the oomycete Phytophthora infestans remains enveloped by host-derived membranes whose functional properties are poorly understood. P. infestans secretes a myriad of effector proteins through these interfaces for plant colonization. Recently we… read more here.
Keywords: pathogen; host autophagy; autophagy machinery; host ... See more keywords