ASPM promotes hepatocellular carcinoma progression by activating Wnt/β‐catenin signaling through antagonizing autophagy‐mediated Dvl2 degradation
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DOI: 10.1002/2211-5463.13278
Abstract: Hepatocellular carcinoma (HCC) is one of the most fatal cancers worldwide. In this article, we show that expression of abnormal spindle‐like microcephaly‐associated protein (ASPM) is up‐regulated in liver cancer samples, and this up‐regulation is significantly… read more here.
Keywords: hepatocellular carcinoma; catenin signaling; autophagy mediated; dvl2 ... See more keywords
Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.08.007
Abstract: Reactive persulfides such as cysteine persulfide and glutathione persulfide are produced by bacteria including Salmonella during sulfur metabolism. The biological significance of bacterial reactive persulfides in host-pathogen interactions still warrants investigation. We found that reactive persulfides… read more here.
Keywords: salmonella typhimurium; autophagy mediated; inhibiting electrophilic; autophagy ... See more keywords
Geraniin inhibits cell growth and promoted autophagy-mediated cell death in the nasopharyngeal cancer C666-1 cells
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.08.076
Abstract: Abstract Background Nasopharyngeal carcinoma (NPC) is a rare malignant tumor developing from epithelial linings of nasopharynx, and 10-50 out of 100,000 NPC cases were recorded globally particularly in the Asian countries. Methodology The cytotoxicity of… read more here.
Keywords: c666 cells; autophagy mediated; cell growth; expressions c666 ... See more keywords
Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01294-0
Abstract: BACKGROUND Activation of mTORC1 plays a significant role in cancer development and progression. However, the metabolic mechanisms to sustain mTORC1 activation of cancer cells within stressed environments are still under-appreciated. We recently revealed high autophagy… read more here.
Keywords: mediated lipid; glioma; lipid catabolism; autophagy mediated ... See more keywords
Transcriptome analysis uncovers the autophagy‐mediated regulatory patterns of the immune microenvironment in dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17455
Abstract: The relationship between autophagy and immunity has been well studied. However, little is known about the role of autophagy in the immune microenvironment during the progression of dilated cardiomyopathy (DCM). Therefore, this study aims to… read more here.
Keywords: autophagy mediated; immune microenvironment; dilated cardiomyopathy; autophagy ... See more keywords
Lw-218, a New Flavonoid Compound, Exerts Anti-T-Cell Malignancies Effects Via Autophagy-Mediated Apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-122409
Abstract: Background:T-cell malignancies are characterized by the excessive proliferation of hematopoietic precursor cells of T-cell lineage lymphocytes in bone marrow. T-cell malignancies consist of T-cell lymphoblastic leukemia (T-ALL) and T-cell non-Hodgkin lymphoma (T-NHL). Effective therapeutic options… read more here.
Keywords: cell malignancies; apoptosis; autophagy mediated; cell ... See more keywords
Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.234120
Abstract: ABSTRACT Post-translational modifications directly control protein activity and, thus, they represent an important means to regulate the responses of cells to different stimuli. Protein SUMOylation has recently been recognised as one such modification, and it… read more here.
Keywords: sumoylation; autophagy mediated; cell death; cancer ... See more keywords
Selenium nanoparticles induce autophagy mediated cell death in human keratinocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Nanomedicine"
DOI: 10.2217/nnm-2018-0397
Abstract: Aim: Selenium nanoparticles (SeNPs) may have a potential role in treating dermal disorders due to its wide therapeutic properties, but there is a need to evaluate its toxicity in keratinocytes. The present study evaluated the… read more here.
Keywords: autophagy mediated; human keratinocytes; cell death; cell ... See more keywords
Osteocytes Enhance Osteogenesis by Autophagy-Mediated FGF23 Secretion Under Mechanical Tension
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DOI: 10.3389/fcell.2021.782736
Abstract: Mechanical stimuli control cell behaviors that are crucial for bone tissue repair. Osteocytes sense extracellular mechanical stimuli then convert them into biochemical signals to harmonize bone remodeling. However, the mechanisms underlying this process remain unclear.… read more here.
Keywords: mechanical tension; autophagy mediated; fgf23 secretion; osteogenesis ... See more keywords
A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF
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DOI: 10.3389/fendo.2022.1057349
Abstract: Heart failure with preserved ejection fraction (HFpEF) is one of the most complex and most prevalent cardiometabolic diseases in aging population. Age, obesity, diabetes, and hypertension are the main comorbidities of HFpEF. Microvascular dysfunction and… read more here.
Keywords: vascular senescence; autophagy mediated; role; senescence ... See more keywords
Potential Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.813703
Abstract: Gastric cancer (GC), second most leading cause of cancer-associated mortality globally, is the cancer of gastrointestinal tract in which malignant cells form in lining of the stomach, resulting in indigestion, pain, and stomach discomfort. Autophagy… read more here.
Keywords: autophagy mediated; gastric cancer; treatment; potential therapeutic ... See more keywords