Pretreatment with vildagliptin boosts ischemic-postconditioning effects on cardioprotection and expression profile of genes regulating autophagy and mitochondrial fission/fusion in diabetic heart with reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01660-z
Abstract: The burden of myocardial ischemia/reperfusion (IR) injury is 2–3-folds higher in diabetic patients, so protecting diabetic hearts is clinically important. Here, we investigated the effect of combinational therapy with vildagliptin and ischemic postconditioning (IPostC) on… read more here.
Keywords: diabetic hearts; vildagliptin; reperfusion; expression ... See more keywords
Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes.
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DOI: 10.1042/cs20160736
Abstract: Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy and mitochondrial dynamics during exercise and recovery is important for skeletal muscle… read more here.
Keywords: skeletal muscle; fission; type diabetes; autophagy mitochondrial ... See more keywords
Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway
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DOI: 10.3892/ol.2018.8177
Abstract: Ginkgolic acids may induce malignant cell death via the B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax)/Bcl-2 apoptosis pathway. Concurrently, apoptosis, autophagy and mitochondrial dysfunction may also be involved in bringing about this endpoint. The anticancer… read more here.
Keywords: apoptosis; ginkgolic acids; apoptosis autophagy; autophagy mitochondrial ... See more keywords