Increased autophagy/mitophagy levels in primary tumours of patients with pancreatic neuroendocrine neoplasms
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine"
DOI: 10.1007/s12020-020-02228-1
Abstract: Background/aims We assessed the levels of autophagy and mitophagy, that are linked to cancer development and drug resistance, in well differentiated pancreatic neuroendocrine neoplasms (PanNENs) and correlated them with clinico-pathological parameters. Methods Fluorescent immunostaining for… read more here.
Keywords: pancreatic neuroendocrine; microscopy; neuroendocrine neoplasms; autophagy mitophagy ... See more keywords
Quantitation of Cardiolipin Binding to Human Autophagy (Mitophagy)-Related Atg-8 Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2136
Abstract: The phospholipid cardiolipin (CL) has been proposed to play a role in selective mitochondrial autophagy, or mitophagy. CL externalization to the outer mitochondrial membrane would act as a signal for the human Atg8 ortholog subfamily,… read more here.
Keywords: cardiolipin binding; quantitation cardiolipin; cardiolipin; autophagy mitophagy ... See more keywords
Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome-Lysosome Fusion.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00275
Abstract: Inhibition of autophagy has been widely viewed as a promising strategy for anticancer therapy. However, few effective and specific autophagy inhibitors have been reported. Herein, we described the design, synthesis, and biological characteristics of new… read more here.
Keywords: cancer; blocking autophagosome; autophagosome lysosome; colorectal cancer ... See more keywords
Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56614-5
Abstract: Dementia is a neurocognitive disorder characterized by a progressive memory loss and impairment in cognitive and functional abilities. Autophagy and mitophagy are two important cellular processes by which the damaged intracellular components are degraded by… read more here.
Keywords: alzheimer disease; autophagy mitophagy; cognitive impairment; impairment ... See more keywords
Thymoquinone (Tq) protects necroptosis induced by autophagy/mitophagy-dependent oxidative stress in human bronchial epithelial cells exposed to cigarette smoke extract (CSE).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13366
Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by cigarette smoke-induced emphysema. Herein, we demonstrate protective effects of Thymoquinone (Tq), an active constituent from Nigella sativa, against cigarette smoke extract (CSE)-induced abnormalities in bronchial epithelial cells.… read more here.
Keywords: cigarette smoke; smoke extract; cse; autophagy mitophagy ... See more keywords
Maternal obesity and offspring health: Adapting metabolic changes through autophagy and mitophagy
Sign Up to like & getrecommendations! Published in 2023 at "Obesity Reviews"
DOI: 10.1111/obr.13567
Abstract: Maternal obesity leads to obstetric complications and a high prevalence of metabolic anomalies in the offspring. Among various contributing factors for maternal obesity‐evoked health sequelae, developmental programming is considered as one of the leading culprit… read more here.
Keywords: obesity; autophagy mitophagy; health; maternal obesity ... See more keywords
The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/2273121
Abstract: The pathogenesis of CRSwNP is complex and unclear. CRSwNP is subdivided into two types based on the infiltration of EOSs: eCRSwNP and noeCRSwNP. This study was designed to seek the role of autophagy, mitophagy, and… read more here.
Keywords: nasal polyps; akt mtor; ecrswnp noecrswnp; autophagy mitophagy ... See more keywords
Abstract 12638: Autophagy-mitophagy Induction Improves Cardiovascular Inflammation in a Murine Model of Kawasaki Disease Vasculitis
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.12638
Abstract: Kawasaki Disease (KD), an acute febrile illness and systemic vasculitis of unknown etiology, is the leading cause of acquired heart disease among children. Recent experimental data from mouse models, as well as clinical, genetic and… read more here.
Keywords: cardiovascular inflammation; autophagy mitophagy; disease; vasculitis ... See more keywords
Autophagy and Mitophagy in Cardiovascular Disease.
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DOI: 10.1161/circresaha.117.311082
Abstract: Autophagy contributes to the maintenance of intracellular homeostasis in most cells of cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth muscle cells. Mitophagy is an autophagic response that specifically targets damaged, and hence potentially… read more here.
Keywords: autophagy mitophagy; autophagy; cardiovascular disease; mitophagy cardiovascular ... See more keywords
The Aging Heart: Mitophagy at the Center of Rejuvenation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2020.00018
Abstract: Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging… read more here.
Keywords: heart; aging heart; mitophagy center; autophagy mitophagy ... See more keywords
The roles of autophagy and mitophagy in corneal pathology: current knowledge and future perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1064938
Abstract: The cornea is the clear dome that covers the front portion of the globe. The primary functions of the cornea are to promote the refraction of light and to protect the eye from invading pathogens,… read more here.
Keywords: roles autophagy; pathology; knowledge; mitophagy corneal ... See more keywords