Targeting autophagy in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.06.002
Abstract: Autophagy plays an important role in plasma cell ontogeny and in the pathophysiology of multiple myeloma. Autophagy is usually considered a pro-survival mechanism, and cooperates with the ubiquitin proteasome system in maintaining the homeostasis of… read more here.
Keywords: targeting autophagy; autophagy multiple; myeloma; multiple myeloma ... See more keywords
Multiple structural rearrangements mediated by high-plasticity regions in Atg3 are key for efficient conjugation of Atg8 to PE during autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1954457
Abstract: ABSTRACT The Atg3 protein is highly homologous from yeast to human. Atg3 functions as an E2-like enzyme promoting conjugation of Atg8-family proteins to phosphatidylethanolamine (PE), a lipid molecule embedded in the growing phagophore membrane during… read more here.
Keywords: autophagy multiple; structural rearrangements; conjugation atg8; autophagy ... See more keywords
Autophagy in Multiple Sclerosis: Two Sides of the Same Coin
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.603710
Abstract: Multiple sclerosis (MS) is a complex auto-immune disorder of the central nervous system (CNS) that involves a range of CNS and immune cells. MS is characterized by chronic neuroinflammation, demyelination, and neuronal loss, but the… read more here.
Keywords: sides coin; autophagy multiple; two sides; multiple sclerosis ... See more keywords