Autophagy is a novel pathway for neurofilament protein degradation in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2124500
Abstract: ABSTRACT How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives in vivo enabling formation of large stable supporting… read more here.
Keywords: microscopy; novel pathway; protein degradation; autophagy novel ... See more keywords
Multisystem involvement, defective lysosomes and impaired autophagy in a novel rat model of nephropathic cystinosis
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac033
Abstract: Abstract Recessive mutations in the CTNS gene encoding the lysosomal transporter cystinosin cause cystinosis, a lysosomal storage disease leading to kidney failure and multisystem manifestations. A Ctns knockout mouse model recapitulates features of cystinosis, but… read more here.
Keywords: kidney; rat model; model; cystinosis ... See more keywords