Reconstruction of Protein-Protein Interaction Networks Using Homology-Based Search: Application to the Autophagy Pathway of Aging in Podospora anserina
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9873-9_4
Abstract: The integration of the available experimental data represents a main problem in systems biology. In particular, in medical sciences, many new data became available, but often data are incomplete and of different quality and quantity.… read more here.
Keywords: protein interaction; interaction networks; protein protein; biology ... See more keywords
Repression of miR-217 protects against high glucose-induced podocyte injury and insulin resistance by restoring PTEN-mediated autophagy pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.145
Abstract: Podocyte damage is the initial hallmark of diabetic nephropathy (DN), leading to the increasing morbidity and mortality in diabetic patients. Recent researches have corroborated the critical roles of miRNAs in the pathological progression of DN.… read more here.
Keywords: insulin; injury insulin; insulin resistance; autophagy pathway ... See more keywords
AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.062
Abstract: The autophagy pathway is an essential facet of the innate immune response, capable of rapidly targeting intracellular bacteria. However, the initial signaling regulating autophagy induction in response to pathogens remains largely unclear. Here, we report that… read more here.
Keywords: detection; response; membrane vesicles; upon detection ... See more keywords
Yunpi Heluo decoction attenuates insulin resistance by regulating SIRT1-FoxO1 autophagy pathway in skeletal muscle of Zucker diabetic fatty rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113828
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Diabetes is a serious chronic metabolic disorder, and type 2 diabetes mellitus (T2DM) accounts for more than 90% of all diabetes cases. Insulin resistance (IR) is an early symptom, typical feature and main… read more here.
Keywords: skeletal muscle; muscle; pathway skeletal; insulin resistance ... See more keywords
Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114772
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cyclocarya paliurus (CP) is a traditional Chinese herb and possesses a variety of biological activities including anti-hyperglycemia, anti-hyperlipidemia, antioxidant and anti-inflammation. Arjunolic acid (AA) is an abundant and bioactive ingredient in CP that… read more here.
Keywords: mtor regulated; regulated autophagy; autophagy pathway; ampk mtor ... See more keywords
Tomorou attenuates progression of rheumatoid arthritis through alteration in ULK-1 independent autophagy pathway in collagen induced arthritis mice model
Sign Up to like & getrecommendations! Published in 2019 at "Cell Death Discovery"
DOI: 10.1038/s41420-019-0222-2
Abstract: Rheumatoid arthritis (RA) is a multifactorial disease which is complicated by apoptosis resistance. Autophagy is one of the key mechanisms which are involved in the development of resistance to apoptosis as well as to the… read more here.
Keywords: extract; mice; rheumatoid arthritis; autophagy pathway ... See more keywords
Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2016.1254864
Abstract: ABSTRACT Selective macroautophagy/autophagy plays a pivotal role in the processing of foreign pathogens and cellular components to maintain homeostasis in human cells. To date, numerous studies have demonstrated the uptake of nanoparticles by cells, but… read more here.
Keywords: selective autophagy; autophagy pathway; bind autophagy; autophagy ... See more keywords
Identification of the autophagy pathway in a mollusk bivalve, Crassostrea gigas
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DOI: 10.1080/15548627.2020.1713643
Abstract: ABSTRACT The Pacific oyster, Crassostrea gigas, is a mollusk bivalve commercially important as a food source. Pacific oysters are subjected to stress and diseases during culture. The autophagy pathway is involved in numerous cellular processes,… read more here.
Keywords: protein; crassostrea gigas; autophagy; autophagy related ... See more keywords
Snx4-assisted vacuolar targeting of transcription factors defines a new autophagy pathway for controlling ATG expression.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1877934
Abstract: Autophagy, in part, is controlled by the repression and activation of autophagy-related (ATG) genes. Here, we describe a new selective autophagy pathway that targets functional transcriptional regulators to control their activity. This pathway is activated… read more here.
Keywords: snx4; snx4 assisted; atg expression; pathway ... See more keywords
Genetic and genomic studies of pathogenic EXOSC2 mutations in the newly described disease SHRF implicate the autophagy pathway in disease pathogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz251
Abstract: Missense mutations in the RNA exosome component Exosome Component 2 (EXOSC2), also known as Ribosomal RNA-processing Protein 4 (RRP4), were recently identified in two unrelated families with a novel syndrome known as Short stature, Hearing… read more here.
Keywords: genomic studies; shrf; pathogenesis; fly rrp4 ... See more keywords
Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article
Sign Up to like & getrecommendations! Published in 2023 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s376380
Abstract: Abstract Mood disorders are disabling conditions that cause significant functional impairment. Due to the clinical heterogeneity and complex nature of these disorders, diagnostic and treatment strategies face challenges. The etiology of mood disorders is multifactorial,… read more here.
Keywords: system; endo lysosomal; lysosomal autophagy; autophagy pathway ... See more keywords