Autophagy pathways in the treatment of prion diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.04.013
Abstract: Prions use cellular machineries for autocatalytic propagation by conformational conversion of the cellular prion protein into the pathological isoform PrPSc. Autophagy is a basic cellular degradation and recycling machinery that delivers cargo to lysosomes. Increase… read more here.
Keywords: prion; treatment prion; pharmacology; prion diseases ... See more keywords
The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105694
Abstract: Mutations in profilin 1 (PFN1) have been identified in rare familial cases of Amyotrophic Lateral Sclerosis (ALS). PFN1 is involved in multiple pathways that could intervene in ALS pathology. However, the specific pathogenic role of… read more here.
Keywords: autophagy pathways; pfn1 mutations; pfn1; lateral sclerosis ... See more keywords