The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.03.002
Abstract: The endoplasmic reticulum (ER) is the site of biogenesis of the isolation membrane (IM, autophagosome precursor) and forms extensive contacts with IMs during their expansion into double-membrane autophagosomes. Little is known about the molecular mechanism… read more here.
Keywords: autophagy proteins; proteins vapa; interact multiple; formation ... See more keywords
Effects of diesel exhaust particles on the expression of tau and autophagy proteins in human neuroblastoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2018.06.007
Abstract: Particulate air pollution is recognized as a potential risk factor for neurological disorders; however, the underlying mechanisms of neurodegenerative diseases that occur due to particulate air pollution remain unclear. The objective of the present study… read more here.
Keywords: proteins human; autophagy proteins; expression tau; tau autophagy ... See more keywords
The double life of autophagy proteins
Sign Up to like & getrecommendations! Published in 2018 at "Nature Microbiology"
DOI: 10.1038/s41564-018-0310-8
Abstract: It is now clear that key autophagy proteins possess alternative functions, distinct from their conventional roles in autophagy. Adding to this emerging field, a new study shows how ATG16L1 acts to promote plasma membrane repair… read more here.
Keywords: double life; autophagy proteins; microbiology; autophagy ... See more keywords
Defensosomes: a new role for autophagy proteins in innate immune defense.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2146894
Abstract: In recent years, the contribution of exosomes to immunity, inflammation and host-pathogen interaction have been appreciated. Exosomes are small secreted extracellular vesicles from endosomal origin that contain a myriad of cellular molecules (protein, nucleic acids),… read more here.
Keywords: new role; autophagy proteins; proteins innate; role autophagy ... See more keywords
Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.258687
Abstract: ABSTRACT The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and lysosomal dysfunction has been implicated in AD pathogenesis. We found, by examining cells stably expressing each… read more here.
Keywords: lysosomal trafficking; apolipoprotein; degradation internalization; autophagy proteins ... See more keywords
Clinical application of autophagy proteins as prognostic biomarkers in colorectal cancer: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2022-0458
Abstract: Aim: To evaluate the prognostic value of autophagy proteins in colorectal cancer (CRC). Methods: Six potential autophagy proteins were analyzed (Beclin-1, LC3A, LC3B, ULK1, ATG10 and p62). Hazard ratios (HRs) and 95% CIs for overall survival (OS) of… read more here.
Keywords: prognostic biomarkers; autophagy proteins; colorectal cancer; p62 ... See more keywords