ABIN1 is a signal‐induced autophagy receptor that attenuates NF‐κB activation by recognizing linear ubiquitin chains
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14323
Abstract: Linear ubiquitin chains play pivotal roles in immune signaling by augmenting NF‐κB activation and suppressing programmed cell death induced by various stimuli. A20‐binding inhibitor of NF‐κB 1 (ABIN1) binds to linear ubiquitin chains and attenuates… read more here.
Keywords: autophagy receptor; attenuates activation; ubiquitin chains; linear ubiquitin ... See more keywords
Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1765521
Abstract: ABSTRACT Macroautophagy/autophagy functions to degrade cellular components and intracellular pathogens. Autophagy receptors, including SQSTM1/p62, target intracellular pathogens. Staphylococcus aureus is a significant pathogen of humans, especially in immunocompromise. S. aureus may use neutrophils as a… read more here.
Keywords: autophagy receptor; staphylococcus aureus; sqstm1 p62; p62 target ... See more keywords
The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.1101/2023.01.27.525901
Abstract: The ubiquitin-binding NBR1 autophagy receptor plays a prominent role in recognizing ubiquitylated protein aggregates for vacuolar degradation by macroautophagy. Here, we show that upon exposing Arabidopsis plants to intense light, NBR1 associates with photodamaged chloroplasts… read more here.
Keywords: clearance; autophagy receptor; nbr1 directs; receptor nbr1 ... See more keywords
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging
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DOI: 10.3389/fcell.2022.793328
Abstract: Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and… read more here.
Keywords: p62 sqstm1; autophagy receptor; selective autophagy; p62 ... See more keywords
The Selective Autophagy Receptor Optineurin in Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00766
Abstract: Autophagy is a pathway that allows cells to target organelles, protein complexes, or invading microorganisms for lysosomal degradation. The specificity of autophagic processes is becoming increasingly recognized and is conferred by selective autophagy receptors such… read more here.
Keywords: selective autophagy; autophagy receptor; autophagy; crohn disease ... See more keywords