Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b10948
Abstract: Autophagy was considered as a double-edged sword that might cooperate, aggravate or antagonize apoptosis. We found that the sonodynamic therapy (SDT) in low dosage induced autophagy might function as a survival pathway for breast cancer… read more here.
Keywords: regulation strategy; via autophagy; breast cancer; autophagy regulation ... See more keywords
The RB1CC1 Claw-binding motif: a new piece in the puzzle of autophagy regulation
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2029234
Abstract: ABSTRACT RB1CC1/FIP200 is a subunit of the ULK1 complex in more complex eukaryotes. This large polypeptide was proposed to be a functional homolog of the Atg17 and Atg11 scaffolding proteins in yeast. Previous studies showed… read more here.
Keywords: claw binding; autophagy regulation; rb1cc1 claw; rb1cc1 ... See more keywords
The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2080957
Abstract: ABSTRACT The assembly of the NLRP3 inflammasome can be initiated by a wide range of stimuli including exogenous infection as well as endogenous damage. Therefore, the tight regulation of the NLRP3 inflammasome is crucial for… read more here.
Keywords: inflammation; ccdc50; autophagy regulation; regulation nlrp3 ... See more keywords
Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/3809308
Abstract: Autophagy is a self-digestive process that degrades intracellular components, including damaged organelles, to maintain energy homeostasis and to cope with cellular stress. Autophagy plays a key role during development and adult tissue homeostasis, and growing… read more here.
Keywords: mitochondrial role; stress; role; autophagy ... See more keywords
Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2019 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-019-1118-0
Abstract: BackgroundCeramide plays pathogenic roles in nonalcoholic fatty liver disease (NAFLD) via multiple mechanisms, and as such inhibition of ceramide de novo synthesis in the liver may be of therapeutically beneficial in patients with NAFLD. In… read more here.
Keywords: effect autophagy; autophagy function; therapeutic effect; hepg2 cells ... See more keywords
Celastrol-mediated autophagy regulation in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Applied Biological Chemistry"
DOI: 10.1186/s13765-020-00565-3
Abstract: In the last few decades, studies on autophagy regulation and its potential role in cancer therapeutics have expanded to include detailed mechanisms. Since apoptosis exhibits drug resistance in some cancers, efforts have focused on searching… read more here.
Keywords: cancer; celastrol mediated; mediated autophagy; autophagy regulation ... See more keywords
How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020304
Abstract: Eukaryotic cells frequently experience fluctuations of the external and internal environments, such as changes in nutrient, energy and oxygen sources, and protein folding status, which, after reaching a particular threshold, become a type of stress.… read more here.
Keywords: mammalian systems; stress; stress yeast; autophagy regulation ... See more keywords
Molecular Mechanism of Autophagy and Its Regulation by Cannabinoids in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13061211
Abstract: Simple Summary This review examines the complex function of autophagy in malignancy and explores its regulation by cannabinoids in different cancers. Autophagy is an important process in the maintenance of cellular homeostasis, through the degradation… read more here.
Keywords: regulation cannabinoids; mechanism; autophagy; autophagy regulation ... See more keywords
Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111912
Abstract: MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes with ~22 nucleotides which are involved in the regulation of post-transcriptional gene expression. Ubiquitination and deubiquitination are common post-translational modifications in eukaryotic cells and… read more here.
Keywords: ubiquitination; ubiquitination system; autophagy regulation; regulation crosstalk ... See more keywords
Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13040957
Abstract: Gut microbiota and the brain are related via a complex bidirectional interconnective network. Thus, intestinal homeostasis is a crucial factor for the brain, as it can control the environment of the central nervous system and… read more here.
Keywords: neurodegeneration; gut; autophagy regulation; gut microbiota ... See more keywords
Autophagy Regulation Using Multimodal Chlorin e6-Loaded Polysilsesquioxane Nanoparticles to Improve Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051548
Abstract: Photodynamic therapy (PDT) is a promising anticancer noninvasive technique that relies on the generation of reactive oxygen species (ROS). Unfortunately, PDT still has many limitations, including the resistance developed by cancer cells to the cytotoxic… read more here.
Keywords: chlorin; therapy; autophagy regulation; photodynamic therapy ... See more keywords