Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy
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DOI: 10.1007/s11892-017-0879-y
Abstract: Purpose of ReviewAutophagy promotes cellular health in response to various cellular stresses and to changes in nutrient conditions. In this review, we focus on the role of autophagy in the pathogenesis of diabetic nephropathy and… read more here.
Keywords: autophagy therapeutic; regulating autophagy; target; diabetic nephropathy ... See more keywords
Autophagy as a therapeutic target in pancreatic cancer
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DOI: 10.1038/s41416-020-01039-5
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterised by early metastasis and resistance to anti-cancer therapy, leading to an overall poor prognosis. Despite continued research efforts, no targeted therapy has yet shown meaningful efficacy in PDAC; mutations… read more here.
Keywords: autophagy therapeutic; pdac; cancer autophagy; cancer ... See more keywords
Autophagy and its therapeutic potential in diabetic nephropathy
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DOI: 10.3389/fendo.2023.1139444
Abstract: Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is the most significant microvascular complication of diabetes and poses a severe public health concern due to a lack of effective clinical treatments. Autophagy is… read more here.
Keywords: stress; therapeutic potential; autophagy therapeutic; potential diabetic ... See more keywords
Targeting Selective Autophagy as a Therapeutic Strategy for Viral Infectious Diseases
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DOI: 10.3389/fmicb.2022.889835
Abstract: Autophagy is an evolutionarily conserved lysosomal degradation system which can recycle multiple cytoplasmic components under both physiological and stressful conditions. Autophagy could be highly selective to deliver different cargoes or substrates, including protein aggregates, pathogenic… read more here.
Keywords: viral infectious; infectious diseases; autophagy therapeutic; targeting selective ... See more keywords