Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
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DOI: 10.1002/2211-5463.13367
Abstract: Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty… read more here.
Keywords: adenoid cystic; autophagy via; salivary adenoid; cystic carcinoma ... See more keywords
FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00856-9
Abstract: Since microglia-associated neuroinflammation plays a pivotal role in the progression of white matter diseases, modulating microglial activation has been suggested as a potential therapeutic strategy. Here, we investigated the anti-inflammatory effects of fingolimod (FTY720) on… read more here.
Keywords: anti inflammatory; fty720; via stat1; autophagy via ... See more keywords
Cannabidiol induces autophagy via ERK1/2 activation in neural cells
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DOI: 10.1038/s41598-021-84879-2
Abstract: Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to the neuroprotection of the central nervous system. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid present in Cannabis sativa. Many therapeutic actions have… read more here.
Keywords: autophagy via; erk1 activation; induces autophagy; cannabidiol induces ... See more keywords
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
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DOI: 10.1080/15548627.2018.1535292
Abstract: ABSTRACT Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be beneficial in neurodegenerative diseases (NDs). The natural compound trehalose promotes autophagy via TFEB (transcription factor EB),… read more here.
Keywords: protein; autophagy via; activation; autophagy related ... See more keywords
The NEDD4-USP13 axis facilitates autophagy via deubiquitinating PIK3C3
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DOI: 10.1080/15548627.2020.1743071
Abstract: ABSTRACT Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in… read more here.
Keywords: nedd4 usp13; axis facilitates; via deubiquitinating; autophagy via ... See more keywords
Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor‐β1/Smads pathway through shikonin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14299
Abstract: Liver fibrosis is a worldwide clinical challenge during the progression of chronic liver disease to liver cirrhosis. Shikonin is extracted from the root of Lithospermum erythrorhizon with antioxidant, anti‐inflammatory, anticancer, and wound‐healing properties. The study… read more here.
Keywords: alleviation hepatic; fibrosis; via inhibition; autophagy via ... See more keywords
Stichoposide C Exerts Anticancer Effects on Ovarian Cancer by Inducing Autophagy via Inhibiting AKT/mTOR Pathway
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DOI: 10.2147/ott.s340556
Abstract: Purpose Stichoposide C (STC) is a triterpene glycoside isolated from Thelenota ananas, which is previously demonstrated to wide spectrum of anticancer effects against various tumor cells. However, the antitumor effects and underlying molecular mechanisms in… read more here.
Keywords: autophagy via; ovarian cancer; microscopy; anticancer effects ... See more keywords
Orexin-A exerts neuroprotective effect in experimental intracerebral hemorrhage by suppressing autophagy via OXR1-mediated ERK/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1045034
Abstract: Background Orexin-A (OXA) is a polypeptide produced in the hypothalamus, which binds to specific receptors and exerts multiple physiological effects. Autophagy plays a vital role in early brain injury (EBI) after intracerebral hemorrhage (ICH). However,… read more here.
Keywords: autophagy via; oxr1 mediated; mediated erk; mtor ... See more keywords
EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.921394
Abstract: Stroke remains one of the leading reasons of mortality and physical disability worldwide. The treatment of cerebral ischemic stroke faces challenges, partly due to a lack of effective treatments. In this study, we demonstrated that… read more here.
Keywords: mtor phosphorylation; autophagy via; ampk mtor; suppressing autophagy ... See more keywords
The Role of Autophagy for the Regeneration of the Aging Liver
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DOI: 10.3390/ijms21103606
Abstract: Age is one of the key risk factors to develop malignant diseases leading to a high incidence of hepatic tumors in the elderly population. The only curative treatment for hepatic tumors is surgical removal, which… read more here.
Keywords: liver regeneration; regeneration; autophagy via; mtor independent ... See more keywords
Melatonin Induces Autophagy via Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells
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DOI: 10.3390/molecules26165038
Abstract: Even though an increasing number of anticancer treatments have been discovered, the mortality rates of colorectal cancer (CRC) have still been high in the past few years. It has been discovered that melatonin has pro-apoptotic… read more here.
Keywords: endoplasmic reticulum; colorectal cancer; autophagy via; reticulum stress ... See more keywords