Dimerization facilitates the conformational transitions for bacterial phosphotransferase enzyme I autophosphorylation in an allosteric manner
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DOI: 10.1002/2211-5463.12260
Abstract: The bacterial phosphotransferase system is central to sugar uptake and phosphorylation. Enzyme I (EI), the first enzyme of the system, autophosphorylates as a dimer using phosphoenolpyruvate (PEP), but it is not clearly understood how dimerization… read more here.
Keywords: bacterial phosphotransferase; dimerization; allosteric manner; autophosphorylation ... See more keywords
Autophosphorylation of the carboxyl‐terminal domain is not required for oncogenic transformation by lung‐cancer derived EGFR mutants
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DOI: 10.1002/ijc.31332
Abstract: Aberrant activation of cancer‐derived mutants of the epidermal growth factor receptor (EGFR) is closely associated with cancer pathogenesis and is thought to be mediated through multiple tyrosine phosphorylations within the C‐terminal domain. Here, we examined… read more here.
Keywords: autophosphorylation; transformation; cancer derived; lung cancer ... See more keywords
Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex.
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DOI: 10.1016/j.celrep.2017.11.076
Abstract: The Hippo pathway controls organ size and tissue homeostasis through a kinase cascade leading from the Ste20-like kinase Hpo (MST1/2 in mammals) to the transcriptional coactivator Yki (YAP/TAZ in mammals). Whereas previous studies have uncovered… read more here.
Keywords: hpo; autophosphorylation; hpo mst; kinase ... See more keywords
Autophosphorylation of the KaiC‐like protein ArlH inhibits oligomerization and interaction with ArlI, the motor ATPase of the archaellum
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DOI: 10.1111/mmi.14781
Abstract: Motile archaea are propelled by the archaellum, whose motor complex consists of the membrane protein ArlJ, the ATPase ArlI, and the ATP‐binding protein ArlH. Despite its essential function and the existence of structural and biochemical… read more here.
Keywords: protein; archaellum; atpase; autophosphorylation ... See more keywords
Autophosphorylation and Cross-Phosphorylation of Protein Kinases from the Crenarchaeon Sulfolobus islandicus
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DOI: 10.3389/fmicb.2017.02173
Abstract: Protein phosphorylation, one of the most important post-translational modifications, regulates almost every cellular process. Although signal transduction by protein phosphorylation is extensively studied in Eukaryotes and Bacteria, the knowledge of this process in archaea is… read more here.
Keywords: protein; sire; islandicus; autophosphorylation ... See more keywords
Inhibitors targeting the autophosphorylation of serine/threonine kinase of Streptococcus suis show potent antimicrobial activity
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DOI: 10.3389/fmicb.2022.990091
Abstract: Antimicrobial resistance (AMR) is a global concern threatening public health. Developing novel antibiotics is one of the effective strategies to tackle AMR. Serine/threonine kinases (STKs) have been recently shown to play critical roles in the… read more here.
Keywords: suis; streptococcus suis; kinase; autophosphorylation ... See more keywords