Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.02.079
Abstract: Summary Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to… read more here.
Keywords: myocardial infarction; autoreactive cells; infarction primes; dendritic cells ... See more keywords
Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103325
Abstract: In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular… read more here.
Keywords: transcriptional landscape; plasmablasts autoreactive; autoreactive cells; landscape plasmablasts ... See more keywords
Regulatory T Cells: From Discovery to Autoimmunity.
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a029041
Abstract: Multiple sclerosis (MS) is a genetically mediated autoimmune disease of the central nervous system. Allelic variants lead to lower thresholds of T-cell activation resulting in activation of autoreactive T cells. Environmental factors, including, among others,… read more here.
Keywords: cells discovery; regulatory cells; autoreactive cells; activation ... See more keywords
Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology
Sign Up to like & getrecommendations! Published in 2019 at "Immunological Reviews"
DOI: 10.1111/imr.12829
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly expanded our understanding of the disease. The best‐known autoantibodies… read more here.
Keywords: protein antibodies; autoantibodies cells; disease; autoreactive cells ... See more keywords
Role of inhibitory signaling in peripheral B cell tolerance *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13070
Abstract: At least 20% of B cells in the periphery expresses an antigen receptor with a degree of self‐reactivity. If activated, these autoreactive B cells pose a risk as they can contribute to the development of… read more here.
Keywords: inhibitory signaling; cell; role inhibitory; tolerance ... See more keywords
Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00707
Abstract: Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity.… read more here.
Keywords: central cell; tolerance; autoreactive cells; differentiation ... See more keywords
Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01794
Abstract: Pemphigus Vulgaris is an autoimmune disease of the skin and mucous membranes, which is due to the production of pathogenic autoantibodies targeting desmoglein (DSG) 1 and 3, which are adhesion proteins of the keratinocytes. Rituximab… read more here.
Keywords: treatment; autoreactive cells; positive cells; expression ... See more keywords
Thymic B Cells as a New Player in the Type 1 Diabetes Response
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.772017
Abstract: Type 1 diabetes (T1d) results from a sustained autoreactive T and B cell response towards insulin-producing β cells in the islets of Langerhans. The autoreactive nature of the condition has led to many investigations addressing… read more here.
Keywords: response; player; autoreactive cells; type diabetes ... See more keywords
Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9080943
Abstract: Multiple sclerosis (MS) is a chronic autoimmune disease mainly caused by autoreactive T cells, followed by neuronal demyelination and disabling paralysis. Hyperbaric oxygen therapy (HBOT) is usually an adjunct to therapy for the treatment of… read more here.
Keywords: central nervous; oxygen therapy; autoreactive cells; autoimmune encephalomyelitis ... See more keywords
Autoreactive T-Cells in Psoriasis: Are They Spoiled Tregs and Can Therapies Restore Their Functions?
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054348
Abstract: Psoriasis is a chronic inflammatory skin disease, which affects 2–4% of the population worldwide. T-cell derived factors such as Th17 and Th1 cytokines or cytokines such as IL-23, which favors Th17-expansion/differentiation, dominate in the disease.… read more here.
Keywords: tregs therapies; psoriasis spoiled; cells psoriasis; autoreactive cells ... See more keywords