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   Articles with "autoreactive cells" as a keyword



Increased Phosphorylation of Intracellular Signaling Molecules Indicates Continuous Activation of Human Autoreactive B‐Cells

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recommendations! Published in 2025 at "European Journal of Immunology"

DOI: 10.1002/eji.202451361

Abstract: Many human autoimmune diseases (AIDs) are hallmarked by the presence and persistence of autoreactive B‐cells. While autoreactive B‐cells may frequently encounter antigens, the signals required to balance and maintain their activation and survival are mostly… read more here.

Keywords: phosphorylation; autoreactive cells; activation; cell ... See more keywords

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells

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recommendations! Published in 2017 at "Cell Reports"

DOI: 10.1016/j.celrep.2017.02.079

Abstract: Summary Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to… read more here.

Keywords: myocardial infarction; autoreactive cells; infarction primes; dendritic cells ... See more keywords

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19

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recommendations! Published in 2021 at "iScience"

DOI: 10.1016/j.isci.2021.103325

Abstract: In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular… read more here.

Keywords: transcriptional landscape; plasmablasts autoreactive; autoreactive cells; landscape plasmablasts ... See more keywords
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Regulatory T Cells: From Discovery to Autoimmunity.

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recommendations! Published in 2018 at "Cold Spring Harbor perspectives in medicine"

DOI: 10.1101/cshperspect.a029041

Abstract: Multiple sclerosis (MS) is a genetically mediated autoimmune disease of the central nervous system. Allelic variants lead to lower thresholds of T-cell activation resulting in activation of autoreactive T cells. Environmental factors, including, among others,… read more here.

Keywords: cells discovery; regulatory cells; autoreactive cells; activation ... See more keywords

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

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recommendations! Published in 2019 at "Immunological Reviews"

DOI: 10.1111/imr.12829

Abstract: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly expanded our understanding of the disease. The best‐known autoantibodies… read more here.

Keywords: protein antibodies; autoantibodies cells; disease; autoreactive cells ... See more keywords

Role of inhibitory signaling in peripheral B cell tolerance *

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recommendations! Published in 2022 at "Immunological Reviews"

DOI: 10.1111/imr.13070

Abstract: At least 20% of B cells in the periphery expresses an antigen receptor with a degree of self‐reactivity. If activated, these autoreactive B cells pose a risk as they can contribute to the development of… read more here.

Keywords: inhibitory signaling; cell; role inhibitory; tolerance ... See more keywords

Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance

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recommendations! Published in 2018 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2018.00707

Abstract: Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity.… read more here.

Keywords: central cell; tolerance; autoreactive cells; differentiation ... See more keywords

Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen

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recommendations! Published in 2019 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2019.01794

Abstract: Pemphigus Vulgaris is an autoimmune disease of the skin and mucous membranes, which is due to the production of pathogenic autoantibodies targeting desmoglein (DSG) 1 and 3, which are adhesion proteins of the keratinocytes. Rituximab… read more here.

Keywords: treatment; autoreactive cells; positive cells; expression ... See more keywords

Thymic B Cells as a New Player in the Type 1 Diabetes Response

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recommendations! Published in 2021 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.772017

Abstract: Type 1 diabetes (T1d) results from a sustained autoreactive T and B cell response towards insulin-producing β cells in the islets of Langerhans. The autoreactive nature of the condition has led to many investigations addressing… read more here.

Keywords: response; player; autoreactive cells; type diabetes ... See more keywords
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Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions

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recommendations! Published in 2021 at "Biomedicines"

DOI: 10.3390/biomedicines9080943

Abstract: Multiple sclerosis (MS) is a chronic autoimmune disease mainly caused by autoreactive T cells, followed by neuronal demyelination and disabling paralysis. Hyperbaric oxygen therapy (HBOT) is usually an adjunct to therapy for the treatment of… read more here.

Keywords: central nervous; oxygen therapy; autoreactive cells; autoimmune encephalomyelitis ... See more keywords

Autoreactive T-Cells in Psoriasis: Are They Spoiled Tregs and Can Therapies Restore Their Functions?

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24054348

Abstract: Psoriasis is a chronic inflammatory skin disease, which affects 2–4% of the population worldwide. T-cell derived factors such as Th17 and Th1 cytokines or cytokines such as IL-23, which favors Th17-expansion/differentiation, dominate in the disease.… read more here.

Keywords: tregs therapies; psoriasis spoiled; cells psoriasis; autoreactive cells ... See more keywords