Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2019.01.108
Abstract: Phencyclidine (PCP) administration is commonly used to model schizophrenia in laboratory animals. While PCP is well-characterized as an antagonist of glutamate-sensitive N-methyl-D-aspartate (NMDA) receptors, its effects on dopamine signaling are not well understood. Here we… read more here.
Keywords: autoreceptor; nigra dopamine; dopamine; substantia nigra ... See more keywords
Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2021.03.09.434538
Abstract: The nanoscopic organization and regulation of individual molecular components in presynaptic varicosities of neurons releasing modulatory volume neurotransmitters like dopamine (DA) remain largely elusive. Here we show by application of several super-resolution microscopy techniques to… read more here.
Keywords: dopamine transporter; drive autoreceptor; inversely regulated; excitatory drive ... See more keywords