tPA variant tPA‐A296–299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET‐1
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DOI: 10.1002/jnr.24112
Abstract: Tissue‐type plasminogen activator (tPA) is neurotoxic and exacerbates uncoupling of cerebral blood flow (CBF) and metabolism after stroke, yet it remains the sole FDA‐approved drug for treatment of ischemic stroke. Upregulation of c‐Jun‐terminal kinase (JNK)… read more here.
Keywords: autoregulation; a296 299; autoregulation necrosis; tpa ... See more keywords
How many squat–stand manoeuvres to assess dynamic cerebral autoregulation?
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DOI: 10.1007/s00421-018-3964-2
Abstract: PurposeSquat–stand manoeuvres (SSMs) have been used to induce blood pressure (BP) changes for the reliable assessment of dynamic cerebral autoregulation. However, they are physically demanding and thus multiple manoeuvres can be challenging for older subjects.… read more here.
Keywords: autoregulation; many squat; dynamic cerebral; squat stand ... See more keywords
Time spent with impaired autoregulation is linked with outcome in severe infant/paediatric traumatic brain injury
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DOI: 10.1007/s00701-017-3308-8
Abstract: BackgroundIt could be shown in traumatic brain injury (TBI) in adults that the functional status of cerebrovascular autoregulation (AR), determined by the pressure reactivity index (PRx), correlates to and even predicts outcome. We investigated PRx,… read more here.
Keywords: autoregulation; outcome; prx; time ... See more keywords
Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats
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DOI: 10.1007/s11357-020-00233-w
Abstract: Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN diabetic model, demonstrates that the myogenic response of the… read more here.
Keywords: autoregulation; blood flow; old rats; blood ... See more keywords
Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK
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DOI: 10.1007/s12975-018-0617-z
Abstract: The sole FDA-approved drug treatment for ischemic stroke is tissue-type plasminogen activator (tPA). However, upregulation of JNK mitogen-activated protein kinase (MAPK) and endothelin 1 (ET-1) by tPA after stroke contributes to impaired cerebrovascular autoregulation. Wild-type… read more here.
Keywords: autoregulation; jnk; upregulation jnk; activation ... See more keywords
Cerebral autoregulation in the operating room and intensive care unit after cardiac surgery.
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DOI: 10.1016/j.bja.2020.12.043
Abstract: BACKGROUND Cerebral autoregulation monitoring is a proposed method to monitor perfusion during cardiac surgery. However, limited data exist from the ICU as prior studies have focused on intraoperative measurements. Our objective was to characterise cerebral… read more here.
Keywords: autoregulation; surgery; operating room; cerebral autoregulation ... See more keywords
Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy
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DOI: 10.1016/j.brainres.2019.04.014
Abstract: Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with… read more here.
Keywords: autoregulation; amyloid angiopathy; cerebral amyloid; phase ... See more keywords
Overcoming the Cost of Positive Autoregulation by Accelerating the Response with a Coupled Negative Feedback
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DOI: 10.1016/j.celrep.2018.08.023
Abstract: SUMMARY A fundamental trade-off between rapid response and optimal expression of genes below cytotoxic levels exists for many signaling circuits, particularly for positively autoregulated systems with an inherent response delay. Here, we describe a regulatory… read more here.
Keywords: autoregulation; cost positive; response; feedback ... See more keywords
Dynamic cerebral autoregulation: A marker of post-operative delirium?☆
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DOI: 10.1016/j.clinph.2018.11.008
Abstract: Abstract Objective We investigated the potential association of cerebral autoregulation (CA) with postoperative delirium (PD), a common complication of cardiac surgery with cardiopulmonary bypass (CPB). Methods In patients undergoing coronary artery bypass graft (CABG) surgery… read more here.
Keywords: autoregulation; surgery; dynamic cerebral; cerebral autoregulation ... See more keywords
Autoregulation of Coronary Blood Supply in Response to Demand: JACC Review Topic of the Week.
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DOI: 10.1016/j.jacc.2021.03.293
Abstract: Although our coronary circulation evolved to meet demands during marked physical exertion for "fight or flight" survival, complex and multilayered control mechanisms reduce flow during other periods. Understanding homeostasis of resting flow provides essential insights… read more here.
Keywords: autoregulation; autoregulation coronary; response demand; blood supply ... See more keywords
Hematoma volume is a predictive factor of disturbed autoregulation after spontaneous intracerebral hemorrhage
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DOI: 10.1016/j.jns.2017.09.035
Abstract: BACKGROUND Dynamic cerebral autoregulation (dCA) is probably disturbed after spontaneous intracerebral hemorrhage (ICH) and could be an independent predictor of clinical outcome. Clinical determinants of dCA status after ICH need to be further elucidated. METHODS… read more here.
Keywords: autoregulation; spontaneous intracerebral; hematoma volume; hematoma ... See more keywords