Ru(II)-catalyzed external auxiliary-free primary amide-directed inverse Sonogashira reaction on (hetero)arylamides.
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DOI: 10.1039/d2cc03929j
Abstract: Herein, we report ruthenium(II)-catalyzed weakly coordinating primary amide-assisted ortho-di-alkynylation of (hetero)arylamides via double C-H bond activation in the presence of bromo-alkynes as coupling partners. The attractive features of the developed strategy lie in the usage… read more here.
Keywords: external auxiliary; reaction; primary amide; auxiliary free ... See more keywords