89Zr-Onartuzumab PET imaging of c-MET receptor dynamics
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-017-3672-x
Abstract: Purposec-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug efficacy or emergence of resistance. Noninvasive visualization of c-MET dynamics could therefore… read more here.
Keywords: nvp auy; auy 922; receptor; onartuzumab pet ... See more keywords
The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice
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DOI: 10.3390/ijms21134740
Abstract: Increased levels of heat shock protein 90 (HSP90) have been recently implicated in the pathogenesis of pulmonary fibrosis and the use of HSP90 inhibitors constitutes a potential therapeutic approach. Similarly, acute exposure to nitrogen mustard… read more here.
Keywords: hsp90; induced pulmonary; auy 922; pulmonary fibrosis ... See more keywords
Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs
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DOI: 10.3390/ph14060522
Abstract: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) cause thousands of deaths every year and are associated with high mortality rates (~40%) due to the lack of efficient therapies. Understanding the molecular mechanisms… read more here.
Keywords: mouse lungs; lps induced; induced inflammation; auy 922 ... See more keywords