Abstract 515: Discovery of potent and orally available small molecule inhibitors of the SOS1-KRAS interaction
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-515
Abstract: Abnormal activating mutation of KRAS is frequently found in many human cancers, including pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), and non-small cell lung cancer (NSCLC). KRAS activating mutations lead to hyperactivation of the MAPK/ERK… read more here.
Keywords: interaction; orally available; discovery potent; sos1 kras ... See more keywords
Comparative Assessment and Multivariate Optimization of Commercially Available Small Scale Reverse Osmosis Membranes
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DOI: 10.3808/jei.201700357
Abstract: Requirement of reverse osmosis (RO) process at places facing energy and water quality problem makes its assessment and optimization vital while considering recovery, rejection as well as specific energy consumption. In the present paper, three… read more here.
Keywords: available small; optimization; commercially available; small scale ... See more keywords