The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag.
Sign Up to like & getrecommendations! Published in 2021 at "Blood reviews"
DOI: 10.1016/j.blre.2021.100909
Abstract: Thrombopoietin regulates platelet production through activation of the thrombopoietin receptor (TPO-R). TPO-R agonists (TPO-RAs) are available to treat thrombocytopenia in chronic immune thrombocytopenia (ITP), chronic liver disease (CLD) patients who are undergoing a procedure, severe… read more here.
Keywords: thrombopoietin; avatrombopag; tpo; thrombopoietin receptor ... See more keywords
An updated evaluation of avatrombopag for the treatment of chronic immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2022.2098119
Abstract: ABSTRACT Introduction Multiple agents are available for the management of chronic immune thrombocytopenia (ITP), including thrombopoietin-receptor agonists (TPO-RAs), rituximab, and fostamatinib. Although TPO-RAs are often selected as treatments for chronic ITP, when choosing between the… read more here.
Keywords: chronic immune; immune thrombocytopenia; tpo ras; avatrombopag ... See more keywords
Avatrombopag for the treatment of thrombocytopenia in patients with chronic liver disease
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2019.1649137
Abstract: ABSTRACT Introduction: Thrombocytopenia is a common hematological abnormality in patients with chronic liver disease (CLD), occurring in 64%~84% of patients with cirrhosis or fibrosis. Due to the increased risk of bleeding, thrombocytopenia potentially affects management… read more here.
Keywords: thrombocytopenia; thrombocytopenia patients; avatrombopag; patients chronic ... See more keywords
Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US study
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18081
Abstract: Patients with immune thrombocytopenia (ITP) may respond to one thrombopoietin receptor agonist (TPO‐RA) but not another. Limited data are available describing outcomes in patients who switched from romiplostim or eltrombopag to avatrombopag, a newer oral… read more here.
Keywords: eltrombopag romiplostim; immune thrombocytopenia; romiplostim; romiplostim eltrombopag ... See more keywords
Effectiveness and Safety of Avatrombopag in Liver Cancer Patients with Severe Thrombocytopenia: Real-World Data and Challenges
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DOI: 10.1155/2022/9138195
Abstract: Background Avatrombopag has been approved in patients who have severe thrombocytopenia ( read more here.
Keywords: liver cancer; severe thrombocytopenia; avatrombopag; treatment ... See more keywords
Analysis of the Efficacy and Safety of Avatrombopag Combined With MSCs for the Treatment of Thrombocytopenia After Allogeneic Hematopoietic Stem Cell Transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.910893
Abstract: Platelet graft failure (PGF) is a frequent and serious complication after Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and lacks effective treatment strategies, which could affect the prognosis of patients and even cause death. The exact… read more here.
Keywords: allogeneic hematopoietic; avatrombopag combined; transplantation; avatrombopag ... See more keywords