Assessment of aversive effects of methylone in male and female Sprague-Dawley rats: Conditioned taste avoidance, body temperature and activity/stereotypies.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2021.106977
Abstract: Methylone's rewarding effects have been well characterized; however, little is known about its aversive effects and how such effects may be impacted by sex. In this context, the present study investigated the aversive effects of… read more here.
Keywords: taste; taste avoidance; aversive effects; sex ... See more keywords
CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Δ9-Tetrahydrocannabinol (Δ9-THC)-Induced Aversive Effects in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12399-z
Abstract: Cannabis can be rewarding or aversive. Cannabis reward is believed to be mediated by activation of cannabinoid CB1 receptors (CB1Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental area (VTA). However, little… read more here.
Keywords: vglut2 expressing; tetrahydrocannabinol thc; glutamatergic neurons; aversive effects ... See more keywords
Nicotine-like discriminative and aversive effects of two α4β2-selective nicotine agonists, ispronicline and metanicotine
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000644
Abstract: An attempt to determine the receptor selective nature of some of nicotine’s behavioral effects was undertaken through the evaluation of the ability of two nicotinic α4β2*-selective receptor agonists to produce nicotine-like effects and modify rates… read more here.
Keywords: two selective; nicotine like; aversive effects; receptor ... See more keywords
Pharmacological activation of kappa opioid receptors in the nucleus accumbens core and ventral tegmental area increases the aversive effects of nicotine
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000675
Abstract: Aversive effects of nicotine play an important role in the development of nicotine dependence. However, neural substrates and/or brain regions that play a role in the aversive effects of nicotine have not been fully identified.… read more here.
Keywords: aversive effects; kappa opioid; effects nicotine; nacc core ... See more keywords
Ethanol-induced conditioned taste aversion and associated neural activation in male rats: Impact of age and adolescent intermittent ethanol exposure
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279507
Abstract: Individuals that initiate alcohol use at younger ages and binge drink during adolescence are more susceptible to developing alcohol use disorder. Adolescents are relatively insensitive to the aversive effects of alcohol and tend to consume… read more here.
Keywords: aversive effects; activation; adolescent intermittent; ethanol ... See more keywords
Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacology Biochemistry and Behavior"
DOI: 10.2139/ssrn.4123465
Abstract: BACKGROUND Polydrug use is well documented in synthetic cathinone users, although the consequences of such use are not well characterized. In pre-clinical research, a pre-exposure to a drug has been reported to attenuate the aversive… read more here.
Keywords: methylone pre; aversive effects; pre exposure; mdpv mdma ... See more keywords
Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13040585
Abstract: Background: Prior work has reported that a drug’s aversive effects (as indexed by taste avoidance conditioning) are attenuated when the pre-exposure and conditioning drugs are the same or different. The latter, otherwise known as cross-drug… read more here.
Keywords: aversive effects; taste avoidance; methylone pre; avoidance ... See more keywords