Catalytic asymmetric total synthesis of diazabicyclooctane β-lactamase inhibitors avibactam and relebactam.
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DOI: 10.1039/d2cc04006a
Abstract: A catalytic asymmetric total synthesis of avibactam and relebactam, two marketed diazabicyclooctane (DBO) β-lactamase inhibitors (BLIs), has been accomplished. An important feature of this study is the creation of a stereogenic center by using Rh-catalysed… read more here.
Keywords: avibactam relebactam; lactamase inhibitors; asymmetric total; total synthesis ... See more keywords