Ceftazidime/avibactam resistance associated with L169P mutation in the omega loop of KPC-2
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DOI: 10.1093/jac/dkz026
Abstract: Objectives Ceftazidime/avibactam resistance due to mutation in the omega loop of KPC-2 has been documented in vitro and in vivo. This study evaluated the mechanism of ceftazidime/avibactam resistance in a KPC-2-expressing Klebsiella pneumoniae isolated from… read more here.
Keywords: ceftazidime avibactam; avibactam resistance; ceftazidime; kpc ... See more keywords
Analyses of a Ceftazidime-Avibactam-Resistant Citrobacter freundii Isolate Carrying blaKPC-2 Reveals a Heterogenous Population and Reversible Genotype
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DOI: 10.1128/msphere.00408-18
Abstract: The development of ceftazidime-avibactam resistance among KPC-producing isolates during treatment with this agent has been reported. Usually isolates that become resistant have a mutated blaKPC gene that confers resistance to ceftazidime-avibactam and susceptibility to meropenem.… read more here.
Keywords: ceftazidime avibactam; avibactam resistance; citrobacter freundii; blakpc ... See more keywords