Synthetic Cancer‐Targeting Innate Immune Stimulators Give Insights into Avidity Effects
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700522
Abstract: Multispecific and multivalent antibodies are seen as promising cancer therapeutics, and numerous antibody fragments and derivatives have been developed to exploit avidity effects that result in increased selectivity. Most of these multispecific and multivalent antibody… read more here.
Keywords: avidity; immune stimulators; cancer; innate immune ... See more keywords
Global koff‐rates of polyclonal T‐cell populations merge subclonal avidities and predict functionality
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149597
Abstract: The avidity of TCRs for peptide‐major histocompatibility complexes (pMHCs) is a governing factor in how T cells respond to antigen. TCR avidity is generally linked to T‐cell functionality and there is growing evidence for distinct… read more here.
Keywords: cell; cell populations; koff rates; avidity ... See more keywords
Differential avidity determination of IgG directed towards the receptor‐binding domain (RBD) of SARS‐CoV‐2 wild‐type and its variants in one assay: Rational tool for the assessment of protective immunity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28006
Abstract: The avidity (binding strength) of IgG directed towards the receptor‐binding domain (RBD) of spike protein has been recognized as a central marker in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) serology. It seems to be… read more here.
Keywords: rbd; igg directed; directed towards; avidity ... See more keywords
Level and avidity of antineutrophil cytoplasmic antibodies specific to lactoferrin are useful biomarkers in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-021-05926-x
Abstract: To evaluate specificity, level, and avidity of antineutrophil cytoplasmic antibodies (ANCA) in systemic lupus erythematosus (SLE). There are no studies of ANCA avidity in SLE. Level (ELISA) and avidity (ELISA) of myeloperoxidase (MPO-), proteinase 3… read more here.
Keywords: level avidity; anca level; avidity; sle ... See more keywords
The Predictive Values of Lesion Size, F-18 FDG Avidity and I-131 Avidity for the Clinical Outcome of I-131 Treatment in Patients with Metastatic Differentiated Thyroid Carcinoma Only in the Lung
Sign Up to like & getrecommendations! Published in 2017 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-017-0502-9
Abstract: PurposeWe aimed to evaluate the prognostic values of radiography, F-18 FDG PET, and I-131 whole body scans in patients with lung-only metastasis from differentiated thyroid carcinoma (DTC).MethodsBetween 1998 and 2013, we included 31 patients (F:… read more here.
Keywords: avid lung; avidity; lung metastasis; lung ... See more keywords
Lung Neoplasms with Low F18-Fluorodeoxyglucose Avidity.
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DOI: 10.1016/j.cpet.2017.08.002
Abstract: Some malignant lung neoplasms may demonstrate low or absent uptake on F18-fluorodeoxyglucose (FDG) PET/computed tomography. Pathologic type and clinical stage are independent factors associated with FDG avidity. Among lung malignancies with low FDG avidity, adenocarcinoma… read more here.
Keywords: avidity; f18 fluorodeoxyglucose; fdg avidity; lung neoplasms ... See more keywords
The potential significance of high avidity immunoglobulin G (IgG) for protective immunity towards SARS-CoV-2
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DOI: 10.1016/j.ijid.2021.01.061
Abstract: Background Avidity is defined as the strength of binding between IgG and its specific target epitope. IgG of high avidity is established during affinity maturation. A failure to achieve high avidity IgG may result in… read more here.
Keywords: avidity; towards sars; high avidity; sars cov ... See more keywords
Establishing tools for early diagnosis of congenital toxoplasmosis: Flow cytometric IgG avidity assay as a confirmatory test for neonatal screening.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2017.08.005
Abstract: The aim of this study was to evaluate the performance of conventional serology (Q-Preven™ and ELFAVIDAS™) and flow cytometry-based serologic tools for early serologic diagnosis of congenital toxoplasmosis. The study groups included prospectively confirmed cases… read more here.
Keywords: avidity; diagnosis congenital; diagnosis; early diagnosis ... See more keywords
Evaluation of an HIV recent infection testing algorithm with serological assays among men who have sex with men in Mexico.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2019.11.002
Abstract: BACKGROUND Human immunodeficiency virus (HIV) incidence should be calculated in cross-sectional studies using recent infection testing algorithms (RITA) that consider clinical variables and serological test results such as enzyme-linked immunosorbent assay (ELISA) and dried blood… read more here.
Keywords: avidity; hiv; recent infection; serological assays ... See more keywords
IgG avidity index and complete blood count as biomarkers of clinical disease in naturally infected dogs with Leishmania infantum.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2018.08.016
Abstract: Canine visceral leishmaniosis (CVL), a parasitic disease caused by Leishmania infantum, may evolve to a chronic condition and lead to death. Evaluation of infected dogs is important to establish the clinical and laboratory parameters involved… read more here.
Keywords: avidity index; clinical disease; avidity; igg avidity ... See more keywords
Biosensor-Enabled Deconvolution of the Avidity-Induced Affinity Enhancement for the SARS-CoV-2 Spike Protein and ACE2 Interaction
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DOI: 10.1021/acs.analchem.1c04372
Abstract: Avidity is an effective and frequent phenomenon employed by nature to achieve extremely high-affinity interactions. As more drug discovery efforts aim to disrupt protein–protein interactions, it is becoming increasingly common to encounter systems that utilize… read more here.
Keywords: sars cov; spike protein; affinity; cov spike ... See more keywords