Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation
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DOI: 10.1126/sciadv.ade7280
Abstract: Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*EC), we show decreased arteriolar tone in vivo during brain AVM initiation. Reduced vascular tone is… read more here.
Keywords: tone; nitric oxide; avm initiation; oxide synthase ... See more keywords