Axin 1 knockdown inhibits osteoblastic apoptosis induced by Porphyromonas gingivalis lipopolysaccharide.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104667
Abstract: BACKGROUND Porphyromonas gingivalis (Pg) is one of the pathogenic bacteria that cause periodontal diseases, lipopolysaccharide (LPS) is the key factor that triggers alveolar bone absorption. This study explored the action of Axin 1 on Pg-LPS-induced… read more here.
Keywords: periodontal diseases; osteoblastic apoptosis; porphyromonas gingivalis; axin knockdown ... See more keywords
Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
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DOI: 10.1038/s41467-025-59984-9
Abstract: Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear. Here, we use nuclear magnetic… read more here.
Keywords: clathrin adaptor; ap2 clathrin; lrp6; axin ... See more keywords
Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.780200
Abstract: Background: Non-small-cell lung cancer (NSCLC) with STK11 mutation showed primary resistance to immune checkpoint inhibitors (ICIs). The glucose-lowering drug metformin exerted anti-cancer effect and enhanced efficacy of chemotherapy in NSCLC with KRAS/STK11 co-mutation, yet it… read more here.
Keywords: metformin; efficacy stk11; stk11; axin ... See more keywords