Axin2-CreERT2 Mediated Knockout of Bone Morphogenetic Protein Receptor Type 1A Caused Abnormal Secondary Dentine and Altered Cell Fate of Axin2-expressing Odontogenic Cells.
Sign Up to like & getrecommendations! Published in 2023 at "International endodontic journal"
DOI: 10.1111/iej.13933
Abstract: AIM Inducing odontogenic differentiation and tubular dentine formation is extremely important in dentine repair and tooth regeneration. BMP signaling plays a critical role in dentine development and tertiary dentine formation, while how BMPR1A-mediated signaling affects… read more here.
Keywords: dentine; cell; secondary dentine; dentine formation ... See more keywords
Loss of β-catenin causes cementum hypoplasia by hampering cementogenic differentiation of Axin2-expressing cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of periodontal research"
DOI: 10.1111/jre.13101
Abstract: BACKGROUND AND OBJECTIVE Although cementum plays an essential role in tooth attachment and adaptation to occlusal force, the regulatory mechanisms of cementogenesis remain largely unknown. We have previously reported that Axin2-expressing (Axin2+ ) mesenchymal cells… read more here.
Keywords: differentiation axin2; axin2 cells; cementum; catenin ... See more keywords
Abstract 2452: A study of AXIN2-regulatory mechanisms and their role in the stem cell origin of human CRC
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DOI: 10.1158/1538-7445.am2023-2452
Abstract: Colorectal cancer (CRC) originates from stem cell (SC) overpopulation, which is driven by constitutively activated WNT-signaling due to mutations in genes that encode components of the WNT-signaling pathway, particularly APC. WNT-signaling is regulated by the… read more here.
Keywords: stem cell; crc; wnt signaling; cancer ... See more keywords
Axin2 Deficiency Causes Hypomineralization and Delayed Tooth Development
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DOI: 10.1177/00220345251342967
Abstract: Axin2 negatively regulates the Wnt signaling pathway, which plays a crucial role in multiple tooth development phases. This study aimed to investigate the effects of Axin2 deficiency on tooth development in zebrafish, which are categorized… read more here.
Keywords: axin2; causes hypomineralization; tooth development; hypomineralization delayed ... See more keywords
Case report expanding the germline AXIN2- related phenotype to include olfactory neuroblastoma and gastric adenoma
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DOI: 10.1186/s12881-020-01103-0
Abstract: Pathogenic AXIN2 variants cause absence of permanent teeth (hypodontia), sparse hair and eye brows (ectodermal dysplasia), and gastrointestinal polyps and cancer. Inheritance is autosomal dominant with variable penetrance. Only twenty- five patients have been reported… read more here.
Keywords: olfactory neuroblastoma; axin2; germline axin2; gastric adenoma ... See more keywords
Detection of a rare AXIN2 variant in an Iranian family with hypodontia and oligodontia
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DOI: 10.34172/joddd.2022.018
Abstract: Background. Hypodontia, or the absence of one or more teeth during tooth formation, is a highly prevalent dental anomaly. Nevertheless, the main causes are still unknown. Mutations in PAX9, MSX1, WNT10A, and AXIN2 genes are… read more here.
Keywords: family; variant; iranian family; hypodontia oligodontia ... See more keywords