Loss of β-catenin causes cementum hypoplasia by hampering cementogenic differentiation of Axin2-expressing cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of periodontal research"
DOI: 10.1111/jre.13101
Abstract: BACKGROUND AND OBJECTIVE Although cementum plays an essential role in tooth attachment and adaptation to occlusal force, the regulatory mechanisms of cementogenesis remain largely unknown. We have previously reported that Axin2-expressing (Axin2+ ) mesenchymal cells… read more here.
Keywords: differentiation axin2; axin2 cells; cementum; catenin ... See more keywords
Activation of Wnt signaling in Axin2+ cells leads to osteodentin formation and cementum overgrowth.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14472
Abstract: OBJECTIVES In this study, we used the mouse incisor model to investigate the regulatory mechanisms of Wnt/β-catenin signaling on Axin2+ cells in tooth development. MATERIALS AND METHODS Axin2lacZ/+ reporter mice were used to define the… read more here.
Keywords: axin2 cells; signaling axin2; mouse; wnt signaling ... See more keywords