Hypothalamic-pituitary-adrenal axis activation in a high-risk sample of children, adolescents and young adults in residential youth care – Associations with adverse childhood experiences and mental health problems
Sign Up to like & getrecommendations! Published in 2020 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2020.112778
Abstract: Adverse childhood experiences (ACEs) lead to devastating long-term health consequences that are associated with a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Children and adolescents living in institutional care have an increased risk to experience ACEs,… read more here.
Keywords: risk; high risk; axis activation; children adolescents ... See more keywords
Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1440592
Abstract: Cerebral ischemic stroke accounts for more than 80% of all stroke cases. During cerebral ischemia, reactive oxygen species produced in the ischemic brain induce oxidative stress and inflammatory responses. Nrf2 is a transcription factor responsible… read more here.
Keywords: brain; ischemic brain; brain injury; axis activation ... See more keywords