A screening study of high affinity peptide as molecular binder for AXL, tyrosine kinase receptor involving in Zika virus entry.
Sign Up to like & getrecommendations! Published in 2020 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2020.107670
Abstract: The recent extensive spread of Zika virus has led to increased interest in the development of early diagnostic tests. To the best of our knowledge, this is the first study to demonstrate the successful use… read more here.
Keywords: axl; affinity; virus entry; spectroscopy ... See more keywords
Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114253
Abstract: The receptor tyrosine kinase (RTK) anexelekto (AXL) is mutated and/or overexpressed in various malignancies, and plays a central role in tumor development and acquired drug resistance. Although highly selective inhibitors have been developed in recent… read more here.
Keywords: tumor; axl degraders; tyrosine kinase; axl ... See more keywords
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02093
Abstract: The receptor tyrosine kinase Axl plays important roles in promoting cancer progression, metastasis, and drug resistance and has been identified as a promising target for anticancer therapeutics. We used molecular modeling-assisted structural optimization starting with… read more here.
Keywords: potent orally; orally bioavailable; axl; bioavailable axl ... See more keywords
Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01346
Abstract: The receptor tyrosine kinase AXL is a promising target for anticancer drug discovery. Herein, we describe the discovery of 3-aminopyrazole derivatives as new potent and selective AXL kinase inhibitors. One of the representative compounds, 6li,… read more here.
Keywords: new potent; aminopyrazole derivatives; axl; discovery aminopyrazole ... See more keywords
MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15877
Abstract: Current treatments for rheumatoid arthritis (RA) do not reverse underlying aberrant immune function. A genetic predisposition to RA, such as HLA-DR4 positivity, indicates that dendritic cells (DC) are of crucial importance to pathogenesis by activating… read more here.
Keywords: axl; mir 34a; 34a dependent; dendritic cells ... See more keywords
MO074TILVESTAMAB, A FUNCTION-BLOCKING MONOCLONAL ANTIBODY INHIBITOR OF AXL RTK SIGNALLING, LIMITS THE ONSET OF RENAL FIBROTIC CHANGES IN HUMAN KIDNEYS EX VIVO
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab078.0010
Abstract: Interstitial fibrosis, characterised by the accumulation of extracellular matrix in the cortical interstitium, is directly correlated with progressive chronic kidney disease secondary to inflammatory, immunologic, obstructive or metabolic causes. An invariant histologic marker of this… read more here.
Keywords: axl; kidney fibrosis; antibody; kidney ... See more keywords
A novel human anti‐AXL monoclonal antibody attenuates tumour cell migration
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12777
Abstract: TAM family members (TYRO3, AXL and MERTK) play essential roles in the resolution of inflammation and in infectious diseases and cancer. AXL, a tyrosine kinase receptor, is commonly overexpressed in several solid tumours and numerous… read more here.
Keywords: tumour cell; axl; cell migration; antibody ... See more keywords
The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aag1064
Abstract: The kinase AXL promotes cetuximab resistance by promoting the nuclear accumulation of EGFR. AXL sends EGFR to the nucleus The receptor tyrosine kinase (RTK) EGFR drives the growth of various cancers. Although a transmembrane protein… read more here.
Keywords: egfr; axl; resistance; receptor ... See more keywords
PO-448 The AP-1 trancriptional complex regulates AXL-induced resistance to PI3K pathway inhibition in head and neck and esophageal cancer
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.959
Abstract: Introduction Phosphoinositide-3-kinase (PI3K) pathway is often hyper activated in Head and Neck and Esopgageal squamous cell carcinoma leading to tumour cell proliferation and survival. Inhibition of the PI3K pathway using the isoform specific inhibitor BYL719,… read more here.
Keywords: byl719; axl; inhibition; resistance ... See more keywords
509 Potent and selective inhibition Of AXL receptor tyrosine kinase for the treatment of cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0509
Abstract: Background AXL receptor tyrosine kinase (AXL) is a transmembrane protein that is over-expressed in a variety of cancer and immune cells. AXL signaling has been implicated in creating an immunosuppressive tumor microenvironment (TME) through both… read more here.
Keywords: axl; kinase; inhibition; cancer ... See more keywords
AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-3142
Abstract: Purpose: Radiation and cetuximab are therapeutics used in management of head and neck squamous cell carcinoma (HNSCC). Despite clinical success with these modalities, development of both intrinsic and acquired resistance is an emerging problem in… read more here.
Keywords: kinase; axl; radiation; cetuximab radiation ... See more keywords