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1
Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114253
Abstract: The receptor tyrosine kinase (RTK) anexelekto (AXL) is mutated and/or overexpressed in various malignancies, and plays a central role in tumor development and acquired drug resistance. Although highly selective inhibitors have been developed in recent…
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Keywords:
tumor;
axl degraders;
tyrosine kinase;
axl ... See more keywords
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4
Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01682
Abstract: AXL kinase is heavily involved in tumorigenesis, metastasis, and drug resistance of many cancers, and several AXL inhibitors are in clinical investigations. Recent studies demonstrated that the N-terminal distal region of AXL plays more important…
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Keywords:
discovery axl;
axl degraders;
improved potencies;
degraders improved ... See more keywords