AXL expression predicts poor prognosis and lack of efficacy of anti-angiogenic and anti-epidermal growth factor receptor (EGFR) agents in patients (pts) with RAS wild type (WT) metastatic colorectal cancer (mCRC)
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz239.032
Abstract: Abstract Background Activation of AXL receptor tyrosine kinase is a key mediator of epithelial to mesenchymal transition (EMT). AXL is overexpressed in several human cancers, including CRC. Methods AXL expression was assessed by immunohistochemistry in… read more here.
Keywords: axl expression; expression; ci95 ci95; anti angiogenic ... See more keywords
AXL Expression in Pediatric AML Is Associated with Putative LSC and Correlates with a Distinct Set of Proteins Associated with Cell Metabolism, Cell Cycle, and Unfolded Protein Response
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112555
Abstract: Background: The receptor tyrosine kinase AXL is emerging as a critical regulator of survival signaling and cell cycle regulators in AML. Our previous work using AXL inhibitor ONO-7475 in treating AML cells demonstrated that the… read more here.
Keywords: protein; axl expression; expression; aml ... See more keywords
Receptor Tyrosine Kinase AXL: A Potential Strategy to Counter Immune Suppression and Dormancy in Multiple Myeloma
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DOI: 10.1182/blood-2019-126834
Abstract: Introduction The AXL receptor tyrosine kinase (AXL) has emerged as a promising therapeutic target for cancer therapy. Recent studies revealed a crucial role of AXL signaling in proliferation, survival, dormancy and therapy resistance in different… read more here.
Keywords: myeloma; dormancy; axl expression; axl ... See more keywords
Combined OPCML and AXL Expression as a Prognostic Marker and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma
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DOI: 10.21873/invivo.12816
Abstract: Background/Aim: Cholangiocarcinoma (CCA) is a type of liver cancer originating from bile duct epithelium which has an unfavorable prognosis. Therefore, novel prognostic markers and effective therapeutic regimens are required. Opioid-binding protein/cell adhesion molecule-like (OPCML) is… read more here.
Keywords: expression; axl inhibitor; opcml; axl expression ... See more keywords
The Significance of Tumor Budding and Immunohistochemical Axl Expression in Gallbladder Adenocarcinomas
Sign Up to like & getrecommendations! Published in 2022 at "Balkan Medical Journal"
DOI: 10.4274/balkanmedj.galenos.2022.2021-9-37
Abstract: Background: Tumor budding is a histopathological finding that is accepted as an indicator of epithelial-mesenchymal transformation in many solid tumors. Axl is a Receptor Tyrosine Kinase (RTK) family member and contributes to epithelial-mesenchymal transformation. It… read more here.
Keywords: tumor budding; axl expression; significance; gallbladder ... See more keywords