Electro-acupuncture Suppresses AXL Expression in Dorsal Root Ganglion Neurons and Enhances Analgesic Effect of AXL Inhibitor in Spinal Nerve Ligation Induced-Neuropathic Pain Rats
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03185-x
Abstract: Electro-acupuncture (EA) has been used for clinic analgesia for many years. However, its mechanisms are not fully understood. We recently reported that AXL, a tyrosine kinase receptor, contributes to the peripheral mechanism of neuropathic pain.… read more here.
Keywords: effect; axl inhibitor; pain; neuropathic pain ... See more keywords
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02093
Abstract: The receptor tyrosine kinase Axl plays important roles in promoting cancer progression, metastasis, and drug resistance and has been identified as a promising target for anticancer therapeutics. We used molecular modeling-assisted structural optimization starting with… read more here.
Keywords: potent orally; orally bioavailable; axl; bioavailable axl ... See more keywords
Abstract C092: Axl inhibitor TP-0903 augments chemo- and immunotherapy efficacy in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c092
Abstract: Pancreatic cancer is the 3rd leading cause of cancer-related deaths in the United States with a 5-year survival less than 9%. Resistance to standard therapy and limited response to immune checkpoint blockade due to the… read more here.
Keywords: axl inhibitor; inhibitor 0903; cancer; 0903 augments ... See more keywords
Effect of inducing HR deficiency using AVB500, a receptor tyrosine kinase AXL inhibitor, on response to olaparib in uterine serous cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e18108
Abstract: e18108Background: Evidence suggests DNA repair is a therapeutic target in endometrial cancer (EC). Given this, we determined whether combination therapy with AVB500, an AXL inhibitor, could improve... read more here.
Keywords: deficiency using; inducing deficiency; axl inhibitor; cancer ... See more keywords
Combined OPCML and AXL Expression as a Prognostic Marker and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.12816
Abstract: Background/Aim: Cholangiocarcinoma (CCA) is a type of liver cancer originating from bile duct epithelium which has an unfavorable prognosis. Therefore, novel prognostic markers and effective therapeutic regimens are required. Opioid-binding protein/cell adhesion molecule-like (OPCML) is… read more here.
Keywords: expression; axl inhibitor; opcml; axl expression ... See more keywords