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   Articles with "axl met" as a keyword



Cabozantinib inhibits AXL- and MET-dependent cancer cell migration induced by growth-arrest-specific 6 and hepatocyte growth factor

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recommendations! Published in 2020 at "Biochemistry and Biophysics Reports"

DOI: 10.1016/j.bbrep.2020.100726

Abstract: Cabozantinib is known as an inhibitor of receptor tyrosine kinases mainly targeting AXL receptor tyrosine kinase (AXL), MET proto-oncogene-encoded receptor tyrosine kinase (MET), and vascular endothelial growth factor receptor 2. Growth arrest-specific 6 (GAS6) and… read more here.

Keywords: cell migration; axl met; migration; cancer ... See more keywords

AXL and MET in Hepatocellular Carcinoma: A Systematic Literature Review

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recommendations! Published in 2022 at "Liver Cancer"

DOI: 10.1159/000520501

Abstract: Background: Multikinase inhibitors (MKIs) have been shown to improve survival in patients with hepatocellular carcinoma (HCC) compared with placebo. Distinct from other MKIs, cabozantinib has inhibitory activity for both AXL and MET. This review considers… read more here.

Keywords: hepatocellular carcinoma; review; hcc; axl met ... See more keywords

AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma

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recommendations! Published in 2022 at "Journal of Personalized Medicine"

DOI: 10.3390/jpm12121993

Abstract: Malignant pleural mesothelioma (MPM) is a highly lethal malignancy that unfortunately cannot benefit from molecularly targeted therapies. Although previous results showed the pivotal role of various receptor tyrosine kinases (RTKs) in MPM tumorigenesis, the treatment… read more here.

Keywords: malignant pleural; pleural mesothelioma; axl met; axl ... See more keywords

AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis.

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recommendations! Published in 2017 at "Oncology reports"

DOI: 10.3892/or.2017.5482

Abstract: The AXL and MET receptors regulate key processes in tumor growth, metastasis, and drug resistance; thus, they have recently been implicated as promising therapeutic targets in various tumors. We investigated the metastatic potential and crosstalk… read more here.

Keywords: inhibition; metastasis; axl met; lung cancer ... See more keywords

PFKP silencing suppresses tumor growth via the AXL-MET axis

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recommendations! Published in 2024 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.100525

Abstract: PFKP (Phosphofructokinase, Platelet Type isoform), as an essential metabolic enzyme, contributes to the high glycolysis rates seen in cancers while its role in oncogenic pathways, especially from a non-metabolic aspect, is not fully understood. We… read more here.

Keywords: pfkp; met axis; axl met; pfkp silencing ... See more keywords