Mouse subthalamic nucleus neurons with local axon collaterals
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24334
Abstract: The neuronal population of the subthalamic nucleus (STN) has the ability to prolong incoming cortical excitation. This could result from intra‐STN feedback excitation. The combination of inducible genetic fate mapping techniques with in vitro targeted… read more here.
Keywords: local axon; stn neurons; subthalamic nucleus; axon ... See more keywords
Ultrasound-Enhanced Molecular Therapy for Axon Neurogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.759
Abstract: An estimated 55M individuals experience spinal cord injuries (SCIs), 230K in the United States. When a nerve is injured, the environment prevents healing of neurons and myelin. This is due to the presence of myelin… read more here.
Keywords: molecular therapy; neurogenesis; ultrasound enhanced; axon ... See more keywords
Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.020
Abstract: Compartmentalized signaling is critical for cellular organization and specificity of functional outcomes in neurons. Here, we report that post-translational lipidation of newly synthesized proteins in axonal compartments allows for short-term and autonomous responses to extrinsic… read more here.
Keywords: axonally translated; translated rac1; prenylation; prenylation axonally ... See more keywords
Rapid and Precise Semi-Automatic Axon Quantification in Human Peripheral Nerves
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-58917-4
Abstract: We developed a time-efficient semi-automated axon quantification method using freeware in human cranial nerve sections stained with paraphenylenediamine (PPD). It was used to analyze a total of 1238 facial and masseteric nerve biopsies. The technique… read more here.
Keywords: semi automatic; axon quantification; human peripheral; automatic axon ... See more keywords
High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1034-x
Abstract: In non-mammalian vertebrates, some neurons can regenerate after spinal cord injury. One of these, the giant Mauthner (M-) neuron shows a uniquely direct link to a robust survival-critical escape behavior but appears to regenerate poorly.… read more here.
Keywords: recovery; microscopy; regeneration; site ... See more keywords
Low levels of NMNAT2 compromise axon development and survival
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy356
Abstract: Abstract Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is an endogenous axon maintenance factor that preserves axon health by blocking Wallerian‐like axon degeneration. Mice lacking NMNAT2 die at birth with severe axon defects in both the peripheral… read more here.
Keywords: compound heterozygote; low levels; mice; axon ... See more keywords
CLARITY reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury
Sign Up to like & getrecommendations! Published in 2019 at "Brain Pathology"
DOI: 10.1111/bpa.12677
Abstract: Diffuse axonal injury (DAI) is an important consequence of traumatic brain injury (TBI). At the moment of trauma, axons rarely disconnect, but undergo cytoskeletal disruption and transport interruption leading to protein accumulation within swellings. The… read more here.
Keywords: pathology; disconnection; brain; axon ... See more keywords
Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15648
Abstract: Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces… read more here.
Keywords: axon growth; inhibition pten; positive sensory; neuronal axon ... See more keywords
Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.258785
Abstract: In neurons, endoplasmic reticulum forms a highly dynamic network that enters axons and presynaptic terminals and plays a central role in Ca2+ homeostasis and synapse maintenance. However, the underlying mechanisms involved in regulation of its… read more here.
Keywords: remodeling ribosomes; endoplasmic reticulum; reticulum; dynamic remodeling ... See more keywords
Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0211073
Abstract: Through forward genetic screening for mutations affecting visual system development, we identified prominent coloboma and cell-autonomous retinal neuron differentiation, lamination and retinal axon projection defects in eisspalte (ele) mutant zebrafish. Additional axonal deficits were present,… read more here.
Keywords: midline axon; loop binding; differentiation; binding protein ... See more keywords
A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.990803
Abstract: The excitatory action of gamma-aminobutyric-acid (GABA) in the median-eminence (ME) led to the steady-state release of corticotropin-releasing hormone (CRH) from CRH axon terminals, which modulates the hypothalamic-pituitary-adrenal (HPA) axis. However, in ME, the source of… read more here.
Keywords: food; axon; corticotropin releasing; eminence led ... See more keywords