The therapeutic potential of berberine chloride against SARM1‐dependent axon degeneration in acrylamide‐induced neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7594
Abstract: Chronic acrylamide (ACR) intoxication causes typical pathology of axon degeneration. Moreover, sterile‐α and toll/interleukin 1 receptor motif‐containing protein 1 (SARM1), the central executioner of the programmed axonal destruction process under various insults, is up‐regulated in… read more here.
Keywords: dependent axon; sarm1 dependent; axon degeneration; berberine chloride ... See more keywords
Neuronal autophagy and axon degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2812-1
Abstract: Axon degeneration is a pathophysiological process of axonal dying and breakdown, which is characterized by several morphological features including the accumulation of axoplasmic organelles, disassembly of microtubules, and fragmentation of the axonal cytoskeleton. Autophagy, a… read more here.
Keywords: autophagy axon; degeneration; axon degeneration; neuronal autophagy ... See more keywords
DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01796-2
Abstract: Axon degeneration is a prominent component of many neurological disorders. Identifying cellular pathways that contribute to axon vulnerability may identify new therapeutic strategies for maintenance of neural circuits. Dual leucine zipper kinase (DLK) is an… read more here.
Keywords: dlk; degeneration; axon survival; sarm1 dependent ... See more keywords
Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02235-3
Abstract: Background TANK-binding kinase1 (TBK1) haploinsufficiency has been shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, the mechanism is unclear. Methods Myeloid Tbk1 knockout mice (Tbk1-LKO mice) were established and motor… read more here.
Keywords: infiltration; myeloid tbk1; tbk1; inflammatory ... See more keywords
Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109872
Abstract: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds,… read more here.
Keywords: sarm1; subvert allosteric; allosteric activation; neurotoxins subvert ... See more keywords
Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.110108
Abstract: Summary Activation of the pro-degenerative protein SARM1 after diverse physical and disease-relevant injuries causes programmed axon degeneration. Original studies indicate that substantially decreased SARM1 levels are required for neuroprotection. However, we demonstrate, in Sarm1 haploinsufficient… read more here.
Keywords: programmed axon; degeneration; axon degeneration; sarm1 levels ... See more keywords
Axon Degeneration: Too Much NMN Is Actually Bad?
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.02.058
Abstract: The mechanism of axon degeneration is incompletely understood. A recent study demonstrates that transgenic expression of bacterial nicotinamide adenine mononucleotide (NMN) in zebrafish and mice, which decreases NMN levels by converting it to NaMN, protects… read more here.
Keywords: much nmn; nmn actually; degeneration much; degeneration ... See more keywords
The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.30.478002
Abstract: Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activation of SARM1… read more here.
Keywords: nad precursor; degeneration; axon degeneration; nmn ... See more keywords
Microtubule‐dependent processes precede pathological calcium influx in excitotoxin‐induced axon degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14909
Abstract: Axon degeneration and axonal loss is a feature of neurodegenerative disease and injury and occurs via programmed pathways that are distinct from cell death pathways. While the pathways of axonal loss following axon severing are… read more here.
Keywords: microtubule; increase; calcium; axonal loss ... See more keywords
Multifaceted roles of SARM1 in axon degeneration and signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.958900
Abstract: Axons are considered to be particularly vulnerable components of the nervous system; impairments to a neuron’s axon leads to an effective silencing of a neuron’s ability to communicate with other cells. Nervous systems have therefore… read more here.
Keywords: degeneration; roles sarm1; axon degeneration; degeneration signaling ... See more keywords
Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00344
Abstract: The development of neuroprotective and repair strategies for treating progressive multiple sclerosis (MS) requires new insights into axonal injury. 4-aminopyridine (4-AP), a blocker of voltage-gated K+ (Kv) channels, is used in symptomatic treatment of progressive… read more here.
Keywords: inflammatory demyelinaton; demyelinaton axon; suppression inflammatory; degeneration inhibiting ... See more keywords