Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation
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DOI: 10.1016/j.celrep.2018.07.081
Abstract: SUMMARY Length-dependent axonopathy of the corticospinal tract causes lower limb spasticity and is characteristic of several neurological disorders, including hereditary spastic paraplegia (HSP) and amyotrophic lateral sclerosis. Mutations in Trk-fused gene (TFG) have been implicated… read more here.
Keywords: hereditary spastic; axon fasciculation; tfg; spastic paraplegia ... See more keywords