Initial axon growth rate from embryonic sensory neurons is correlated with birth date
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22743
Abstract: Axon growth rate from different populations of sensory neurons is correlated with the distance they have to grow to reach their targets in development: neurons with more distant targets extend axons at intrinsically faster rates.… read more here.
Keywords: growth; birth date; growth rate; axon growth ... See more keywords
3D axon growth by exogenous electrical stimulus and soluble factors
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.10.032
Abstract: Axon growth and alignment are fundamental processes during nervous system development and neural regeneration after injury. The present study investigates the effects of exogenous stimulus of electrical signals and soluble factors on axon 3D growth,… read more here.
Keywords: axon growth; field; electrical stimulus; soluble factors ... See more keywords
TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.09.007
Abstract: &NA; We have studied the role of the tumor necrosis factor superfamily member APRIL in the development of embryonic mouse midbrain dopaminergic neurons in vitro and in vivo. In culture, soluble APRIL enhanced axon growth… read more here.
Keywords: nigrostriatal projection; midbrain dopaminergic; axon growth; member april ... See more keywords
Alteration in global DNA methylation status following preconditioning injury influences axon growth competence of the sensory neurons
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113177
Abstract: Preconditioning peripheral nerve injury primes the sensory neurons in the dorsal root ganglia (DRGs) to acquire axon regeneration competence. Transcription of a large set of regeneration-associated-genes (RAGs) contributes to the enhanced intrinsic axonal regeneration capacity.… read more here.
Keywords: dna methylation; injury; axon growth; dna ... See more keywords
Identification of the extracellular matrix protein Fibulin-2 as a regulator of spinal nerve organization.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.06.014
Abstract: During amniote peripheral nervous system development, segmentation ensures the correct patterning of the spinal nerves relative to the vertebral column. Along the antero-posterior (rostro-caudal) axis, each somite-derived posterior half-sclerotome expresses repellent molecules to restrict axon… read more here.
Keywords: spinal nerve; matrix protein; axon growth; extracellular matrix ... See more keywords
Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0064-0
Abstract: Neurons in the central nervous system (CNS) lose their intrinsic ability and fail to regenerate, but the underlying mechanisms are largely unknown. Polycomb group (PcG) proteins, which include PRC1 and PRC2 complexes function as gene… read more here.
Keywords: growth regeneration; axon growth; polycomb; regeneration ... See more keywords
Holding back axon growth
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-019-0249-7
Abstract: RHOA drives the formation of actin arcs in neuronal growth cones in mice, limiting microtubule protrusion and restricting axon growth. read more here.
Keywords: growth; holding back; back axon; axon growth ... See more keywords
Genetic variants in autism-related CNTNAP2 impair axonal growth of cortical neurons
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy102
Abstract: The CNTNAP2 gene, coding for the cell adhesion glycoprotein Caspr2, is thought to be one of the major susceptibility genes for autism spectrum disorder (ASD). A large number of rare heterozygous missense CNTNAP2 variants have… read more here.
Keywords: axon growth; autism; genetic variants; axonal growth ... See more keywords
Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15648
Abstract: Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces… read more here.
Keywords: axon growth; inhibition pten; positive sensory; neuronal axon ... See more keywords
GIT1 Promotes Axonal Growth in an Inflammatory Environment by Promoting the Phosphorylation of MAP1B
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7474177
Abstract: Spinal cord injury (SCI) is a severe traumatic condition. The loss of the bundle of axons involved in motor conduction in the spinal cord after SCI is the main cause of motor function injury. Presently,… read more here.
Keywords: environment; axon growth; git1; growth inflammatory ... See more keywords
MiR-124 Promotes the Growth of Retinal Ganglion Cells Derived from Müller Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000487292
Abstract: Background/Aims: Retinal Müller cells could be induced to differentiate into retinal ganglion cells (RGCs), but RGCs derived from Müller cells have defects in axon growth, leading to a defect in signal conduction. In this study… read more here.
Keywords: derived ller; mir 124; axon growth; ller cells ... See more keywords