SNARE proteins play a role in motor axon guidance in vertebrates and invertebrates
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22481
Abstract: Axonal growth and guidance rely on correct growth cone responses to guidance cues, both in the central nervous system (CNS) and in the periphery. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics,… read more here.
Keywords: axon guidance; snare proteins; guidance; motor axon ... See more keywords
A new model for netrin1 in commissural axon guidance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24117
Abstract: Now‐classic experiments characterized netrin1 as a major player in commissural axon guidance in the spinal cord. The data suggest a chemotactic model in which netrin1 expression in the floor plate forms a concentration gradient that… read more here.
Keywords: netrin1 commissural; new model; commissural axon; axon guidance ... See more keywords
Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model
Sign Up to like & getrecommendations! Published in 2019 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2019.04.006
Abstract: In autism spectrum disorder (ASD), disrupted functional and structural connectivity in the social brain has been suggested as the core biological mechanism underlying the social recognition deficits of this neurodevelopmental disorder. In this study, we… read more here.
Keywords: anterior commissure; axon guidance; model; abnormal axon ... See more keywords
Glia initiate brain assembly through non-canonical Chimaerin/Furin axon guidance in C. elegans
Sign Up to like & getrecommendations! Published in 2017 at "Nature neuroscience"
DOI: 10.1038/nn.4630
Abstract: Brain assembly is hypothesized to begin when pioneer axons extend over non-neuronal cells, forming tracts guiding follower axons. Yet pioneer-neuron identities, their guidance substrates, and their interactions are not well understood. Here, using time-lapse embryonic… read more here.
Keywords: brain assembly; guidance; follower; axon guidance ... See more keywords
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15211-1
Abstract: Axon pathfinding is critical for nervous system development, and it is orchestrated by molecular cues that activate receptors on the axonal growth cone. Robo family receptors bind Slit guidance cues to mediate axon repulsion. In… read more here.
Keywords: robo3; axon guidance; activation axon; family ... See more keywords
Filtering out the noise in axon guidance
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-019-0162-0
Abstract: An intracellular molecule acts in a context-dependent manner to suppress responses to irrelevant guidance cues during axon development. read more here.
Keywords: guidance; filtering noise; noise axon; axon guidance ... See more keywords
Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72828-4
Abstract: Intra-retinal axon guidance involves a coordinated expression of transcription factors, axon guidance genes, and secretory molecules within the retina. Pax6, the master regulator gene, has a spatio-temporal expression typically restricted till neurogenesis and fate-specification. However,… read more here.
Keywords: pax6; intra retinal; axon guidance; guidance ... See more keywords
Characterization of enhancer fragments in Drosophila robo2
Sign Up to like & getrecommendations! Published in 2022 at "Fly"
DOI: 10.1080/19336934.2022.2126259
Abstract: Receptor proteins of the Roundabout (Robo) family regulate axon guidance decisions during nervous system development. Among the three Drosophila robo family genes (robo1, robo2, and robo3), robo2 displays a dynamic expression pattern and regulates multiple… read more here.
Keywords: dynamic expression; expression pattern; expression; robo2 ... See more keywords
MicroRNA alterations in induced Pluripotent Stem Cell-derived neurons from bipolar disorder patients: pathways involved in neuronal differentiation, axon guidance and plasticity.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cells and development"
DOI: 10.1089/scd.2020.0046
Abstract: Bipolar disorder (BP) is a complex psychiatric condition characterized by severe fluctuations in mood for which underlying pathological mechanisms remain unclear. Family and twin studies have identified a hereditary component to the disorder, but a… read more here.
Keywords: disorder; derived neurons; axon guidance; bipolar disorder ... See more keywords
Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9411276
Abstract: Schizophrenia (SZ) is a complex disorder caused by a variety of genetic and environmental factors. Mounting evidence suggests the involvement of microRNAs (miRNAs) in the pathology of SZ. Accordingly, the current study set out to… read more here.
Keywords: inhibition; 183 cluster; 182 183; mir 182 ... See more keywords
The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006865
Abstract: WAGR syndrome is characterized by Wilm’s tumor, aniridia, genitourinary abnormalities and intellectual disabilities. WAGR is caused by a chromosomal deletion that includes the PAX6, WT1 and PRRG4 genes. PRRG4 is proposed to contribute to the… read more here.
Keywords: gene; axon guidance; wagr syndrome; prrg4 functional ... See more keywords