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   Articles with "axon guidance" as a keyword



SNARE proteins play a role in motor axon guidance in vertebrates and invertebrates

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recommendations! Published in 2017 at "Developmental Neurobiology"

DOI: 10.1002/dneu.22481

Abstract: Axonal growth and guidance rely on correct growth cone responses to guidance cues, both in the central nervous system (CNS) and in the periphery. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics,… read more here.

Keywords: axon guidance; snare proteins; guidance; motor axon ... See more keywords

Rho GTPase Signaling: A Molecular Switchboard for Regulating the Actin Cytoskeleton in Axon Guidance

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recommendations! Published in 2025 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.70005

Abstract: Axon pathfinding is a highly dynamic process regulated by the interactions between cell‐surface guidance receptors and guidance cues present in the extracellular environment. During development, precise axon pathfinding is crucial for the formation of functional… read more here.

Keywords: actin cytoskeleton; axon guidance; guidance; rho gtpase ... See more keywords

A new model for netrin1 in commissural axon guidance

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recommendations! Published in 2018 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24117

Abstract: Now‐classic experiments characterized netrin1 as a major player in commissural axon guidance in the spinal cord. The data suggest a chemotactic model in which netrin1 expression in the floor plate forms a concentration gradient that… read more here.

Keywords: netrin1 commissural; new model; commissural axon; axon guidance ... See more keywords
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Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model

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recommendations! Published in 2019 at "NeuroImage"

DOI: 10.1016/j.neuroimage.2019.04.006

Abstract: In autism spectrum disorder (ASD), disrupted functional and structural connectivity in the social brain has been suggested as the core biological mechanism underlying the social recognition deficits of this neurodevelopmental disorder. In this study, we… read more here.

Keywords: anterior commissure; axon guidance; model; abnormal axon ... See more keywords

Glia initiate brain assembly through non-canonical Chimaerin/Furin axon guidance in C. elegans

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recommendations! Published in 2017 at "Nature neuroscience"

DOI: 10.1038/nn.4630

Abstract: Brain assembly is hypothesized to begin when pioneer axons extend over non-neuronal cells, forming tracts guiding follower axons. Yet pioneer-neuron identities, their guidance substrates, and their interactions are not well understood. Here, using time-lapse embryonic… read more here.

Keywords: brain assembly; guidance; follower; axon guidance ... See more keywords

NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-15211-1

Abstract: Axon pathfinding is critical for nervous system development, and it is orchestrated by molecular cues that activate receptors on the axonal growth cone. Robo family receptors bind Slit guidance cues to mediate axon repulsion. In… read more here.

Keywords: robo3; axon guidance; activation axon; family ... See more keywords
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Filtering out the noise in axon guidance

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recommendations! Published in 2019 at "Nature Reviews Neuroscience"

DOI: 10.1038/s41583-019-0162-0

Abstract: An intracellular molecule acts in a context-dependent manner to suppress responses to irrelevant guidance cues during axon development. read more here.

Keywords: guidance; filtering noise; noise axon; axon guidance ... See more keywords
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Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-72828-4

Abstract: Intra-retinal axon guidance involves a coordinated expression of transcription factors, axon guidance genes, and secretory molecules within the retina. Pax6, the master regulator gene, has a spatio-temporal expression typically restricted till neurogenesis and fate-specification. However,… read more here.

Keywords: pax6; intra retinal; axon guidance; guidance ... See more keywords

Characterization of enhancer fragments in Drosophila robo2

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recommendations! Published in 2022 at "Fly"

DOI: 10.1080/19336934.2022.2126259

Abstract: Receptor proteins of the Roundabout (Robo) family regulate axon guidance decisions during nervous system development. Among the three Drosophila robo family genes (robo1, robo2, and robo3), robo2 displays a dynamic expression pattern and regulates multiple… read more here.

Keywords: dynamic expression; expression pattern; expression; robo2 ... See more keywords

MicroRNA alterations in induced Pluripotent Stem Cell-derived neurons from bipolar disorder patients: pathways involved in neuronal differentiation, axon guidance and plasticity.

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recommendations! Published in 2020 at "Stem cells and development"

DOI: 10.1089/scd.2020.0046

Abstract: Bipolar disorder (BP) is a complex psychiatric condition characterized by severe fluctuations in mood for which underlying pathological mechanisms remain unclear. Family and twin studies have identified a hereditary component to the disorder, but a… read more here.

Keywords: disorder; derived neurons; axon guidance; bipolar disorder ... See more keywords

A human DCC variant causing mirror movement disorder reveals that the WAVE regulatory complex mediates axon guidance by netrin-1–DCC

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recommendations! Published in 2024 at "Science Signaling"

DOI: 10.1126/scisignal.adk2345

Abstract: The axon guidance cue netrin-1 signals through its receptor DCC (deleted in colorectal cancer) to attract commissural axons to the midline. Variants in DCC are frequently associated with congenital mirror movements (CMMs). A CMM-associated variant… read more here.

Keywords: mirror; variant; axon guidance; dcc ... See more keywords