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   Articles with "axon initial" as a keyword



The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

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recommendations! Published in 2017 at "Developmental Psychobiology"

DOI: 10.1002/dev.21453

Abstract: Plasticity of the axon initial segment (AIS) is a newly discovered type of structural plasticity that regulates cell excitability. AIS plasticity has been reported to happen during normal development of neocortex and also in a… read more here.

Keywords: initial segment; plasticity axon; axon initial; ais ... See more keywords

Glucose increases the length and spacing of the lattice structure of the axon initial segment

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recommendations! Published in 2022 at "Microscopy Research and Technique"

DOI: 10.1002/jemt.24122

Abstract: The axon initial segment (AIS) plays an important role in maintaining neuronal polarity and initiating action potentials (APs). The AIS adapts to its environment by changing its length and distance from the cell body, resulting… read more here.

Keywords: structure; microscopy; lattice structure; ais plasticity ... See more keywords

Modifications of the axon initial segment during the hibernation of the Syrian hamster

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recommendations! Published in 2018 at "Brain Structure and Function"

DOI: 10.1007/s00429-018-1753-7

Abstract: Mammalian hibernation is a natural process in which the brain undergoes profound adaptive changes that appear to protect the brain from extreme hypoxia and hypothermia. In addition to a virtual cessation of neural and metabolic… read more here.

Keywords: initial segment; axon initial; hibernation; hibernation syrian ... See more keywords
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Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure.

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recommendations! Published in 2021 at "Molecular neurobiology"

DOI: 10.1007/s12035-021-02531-6

Abstract: The axon initial segment (AIS) is essential for maintaining neuronal polarity, modulating protein transport into the axon, and action potential generation. These functions are supported by a distinctive actin and microtubule cytoskeleton that controls axonal… read more here.

Keywords: initial segment; axon initial; ais; density ... See more keywords

Cilia function is associated with axon initial segment morphology.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.05.172

Abstract: Cilia, as key integrators of extracellular ligand-based signaling, play a critical role in signaling in the neuronal system. However, the function of cilia in neurons is largely unknown. In this study, we discovered that cilia… read more here.

Keywords: axon initial; associated axon; morphology; function ... See more keywords
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A constitutively-active IKK-complex at the axon initial segment

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2017.10.020

Abstract: BACKGROUND Previous studies provided evidence for an accumulation of IκB-kinase (IKK) α/β at the axon initial segment (AIS), a neuronal compartment defined by ankyrin-G expression. Here we explored whether the presence of the IKK-complex at… read more here.

Keywords: initial segment; axon initial; constitutively active; ikk ... See more keywords

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.02.060

Abstract: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiological function… read more here.

Keywords: initial segment; axon initial; tmem106b; ftld risk ... See more keywords

Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder

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recommendations! Published in 2022 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2021.105273

Abstract: The axon initial segment (AIS) is a structural neuronal compartment of the proximal axon that plays key roles in sodium channel clustering, action potential initiation, and signal propagation of neuronal outputs. Mutations in constitutive genes… read more here.

Keywords: ais length; disorder; initial segment; neurodevelopmental disorders ... See more keywords

A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-66120-0

Abstract: Protein phosphorylation plays a crucial role in regulating the cytoskeletal and membrane proteins at the axon initial segment (AIS). However, our knowledge of AIS-specific kinases and phosphatases is very limited. Here, we report the identification… read more here.

Keywords: protein phosphorylation; initial segment; subunit; axon initial ... See more keywords

Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2400709121

Abstract: Significance In this study, we propose a model of ARHGEF9-DEE in which the effects of impaired inhibition and protein aggregations converge at the axon initial segment (AIS) and cooperate to produce neuronal network hyperexcitability leading… read more here.

Keywords: epileptic encephalopathy; structure function; axon initial; developmental epileptic ... See more keywords

The axon initial segment as a source of neuropathic pain

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recommendations! Published in 2022 at "Brain"

DOI: 10.1093/brain/awac156

Abstract: This scientific commentary refers to ‘Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain’ by Nascimento et al. (https://doi.org/10.1093/brain/awac078). read more here.

Keywords: initial segment; neuropathic pain; axon initial; segment source ... See more keywords