The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Psychobiology"
DOI: 10.1002/dev.21453
Abstract: Plasticity of the axon initial segment (AIS) is a newly discovered type of structural plasticity that regulates cell excitability. AIS plasticity has been reported to happen during normal development of neocortex and also in a… read more here.
Keywords: initial segment; plasticity axon; axon initial; ais ... See more keywords
Glucose increases the length and spacing of the lattice structure of the axon initial segment
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24122
Abstract: The axon initial segment (AIS) plays an important role in maintaining neuronal polarity and initiating action potentials (APs). The AIS adapts to its environment by changing its length and distance from the cell body, resulting… read more here.
Keywords: structure; microscopy; lattice structure; ais plasticity ... See more keywords
Modifications of the axon initial segment during the hibernation of the Syrian hamster
Sign Up to like & getrecommendations! Published in 2018 at "Brain Structure and Function"
DOI: 10.1007/s00429-018-1753-7
Abstract: Mammalian hibernation is a natural process in which the brain undergoes profound adaptive changes that appear to protect the brain from extreme hypoxia and hypothermia. In addition to a virtual cessation of neural and metabolic… read more here.
Keywords: initial segment; axon initial; hibernation; hibernation syrian ... See more keywords
Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02531-6
Abstract: The axon initial segment (AIS) is essential for maintaining neuronal polarity, modulating protein transport into the axon, and action potential generation. These functions are supported by a distinctive actin and microtubule cytoskeleton that controls axonal… read more here.
Keywords: initial segment; axon initial; ais; density ... See more keywords
Cilia function is associated with axon initial segment morphology.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.172
Abstract: Cilia, as key integrators of extracellular ligand-based signaling, play a critical role in signaling in the neuronal system. However, the function of cilia in neurons is largely unknown. In this study, we discovered that cilia… read more here.
Keywords: axon initial; associated axon; morphology; function ... See more keywords
A constitutively-active IKK-complex at the axon initial segment
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.10.020
Abstract: BACKGROUND Previous studies provided evidence for an accumulation of IκB-kinase (IKK) α/β at the axon initial segment (AIS), a neuronal compartment defined by ankyrin-G expression. Here we explored whether the presence of the IKK-complex at… read more here.
Keywords: initial segment; axon initial; constitutively active; ikk ... See more keywords
The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.060
Abstract: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiological function… read more here.
Keywords: initial segment; axon initial; tmem106b; ftld risk ... See more keywords
Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105273
Abstract: The axon initial segment (AIS) is a structural neuronal compartment of the proximal axon that plays key roles in sodium channel clustering, action potential initiation, and signal propagation of neuronal outputs. Mutations in constitutive genes… read more here.
Keywords: ais length; disorder; initial segment; neurodevelopmental disorders ... See more keywords
The axon initial segment as a source of neuropathic pain
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac156
Abstract: This scientific commentary refers to ‘Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain’ by Nascimento et al. (https://doi.org/10.1093/brain/awac078). read more here.
Keywords: initial segment; neuropathic pain; axon initial; segment source ... See more keywords
Quantitative analysis of the GABAergic innervation of the soma and axon initial segment of pyramidal cells in the human and mouse neocortex.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac314
Abstract: Perisomatic GABAergic innervation in the cerebral cortex is carried out mostly by basket and chandelier cells, which differentially participate in the control of pyramidal cell action potential output and synchronization. These cells establish multiple synapses… read more here.
Keywords: initial segment; gabaergic innervation; axon initial; human mouse ... See more keywords
ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddad081
Abstract: PURPOSE To characterize a novel neurodevelopmental syndrome due to loss-of-function (LoF) variants in Ankyrin 2 (ANK2), and to explore the effects on neuronal network dynamics and homeostatic plasticity in human induced pluripotent stem cell-derived neurons.… read more here.
Keywords: network; loss function; plasticity; activity ... See more keywords