Morin improves functional recovery after spinal cord injury in rats by enhancing axon regeneration via the Nrf2/HO‐1 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7234
Abstract: Spinal cord injury (SCI) is a devastating neurological occurrence that usually leads to a loss of motor and sensory function in patients. Axon regeneration has been reported to be crucial for recovery after trauma to… read more here.
Keywords: recovery; axon regeneration; regeneration; morin ... See more keywords
Dual Oxidase Mutant Retards Mauthner-Cell Axon Regeneration at an Early Stage via Modulating Mitochondrial Dynamics in Zebrafish.
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience bulletin"
DOI: 10.1007/s12264-020-00600-9
Abstract: Dual oxidase (duox)-derived reactive oxygen species (ROS) have been correlated with neuronal polarity, cerebellar development, and neuroplasticity. However, there have not been many comprehensive studies of the effect of individual duox isoforms on central-axon regeneration… read more here.
Keywords: axon regeneration; mauthner cell; regeneration; dual oxidase ... See more keywords
Alternative RNA splicing associated with axon regeneration after rat peripheral nerve injury
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.07.003
Abstract: Abstract The intrinsic axon regeneration capacity is crucial for peripheral nerve regeneration after injury. Identifying key molecules involved in this process makes great contribution to the investigation of peripheral nerve injury repair. Alternative splicing (AS)… read more here.
Keywords: axon regeneration; sciatic nerve; regeneration; nerve injury ... See more keywords
Unfolded protein response-induced expression of long noncoding RNA Ngrl1 supports peripheral axon regeneration by activating the PI3K-Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2022.114025
Abstract: In mammals, long noncoding RNA (LncRNA) contributes to neuronal development and injury repair mediated by the spatiotemporal regulation of gene expression. However, the pivotal role of lncRNA in intrinsic axon regeneration control following a nerve… read more here.
Keywords: axon regeneration; expression; protein response; unfolded protein ... See more keywords
Axon Regeneration: Antagonistic Signaling Pairs in Neuronal Polarization.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.05.007
Abstract: Genome-wide screens, proteomics, and candidate-based approaches have identified numerous genes associated with neuronal regeneration following central nervous system (CNS) injury. Despite significant progress, functional recovery remains a challenge, even in model systems. Neuronal function depends… read more here.
Keywords: axon regeneration; neuronal polarization; polarization axon; signaling pairs ... See more keywords
Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.04.033
Abstract: Despite robust effects on immature neurons, growth factors minimally promote axon regeneration in the adult central nervous system (CNS). Attempting to improve growth-factor responsiveness in mature neurons by dedifferentiation, we overexpressed Lin28 in the retina.… read more here.
Keywords: growth factor; axon regeneration; growth; factor responsiveness ... See more keywords
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.05.044
Abstract: Neuronal subtypes show diverse injury responses, but the molecular underpinnings remain elusive. Using transgenic mice that allow reliable visualization of axonal fate, we demonstrate that intrinsically photosensitive retinal ganglion cells (ipRGCs) are both resilient to… read more here.
Keywords: axon regeneration; retinal ganglion; regeneration; ganglion cells ... See more keywords
Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.07.004
Abstract: Phase separation into liquid-like compartments is an emerging property of proteins containing prion-like domains (PrLDs), yet the in vivo roles of phase separation remain poorly understood. TIA proteins contain a C-terminal PrLD, and mutations in the… read more here.
Keywords: axon regeneration; inhibition; regeneration; tiar ... See more keywords
Return of function after CNS axon regeneration: Lessons from injury-responsive intrinsically photosensitive and alpha retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2018.11.006
Abstract: This review addresses issues relating to the survival and axon regeneration of both intrinsically photosensitive retinal ganglion cells (ipRGC) and αRGC, and possible ensuing patterns of functional recovery after optic nerve crush, all of which… read more here.
Keywords: axon regeneration; retinal ganglion; regeneration; ganglion cells ... See more keywords
Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05478-w
Abstract: Following axon injury, a cascade of signaling events is triggered to initiate axon regeneration. However, the mechanisms regulating axon regeneration are not well understood at present. In Caenorhabditis elegans, axon regeneration utilizes many of the… read more here.
Keywords: phosphatidylserine exposure; axon regeneration; abc transporter; regeneration ... See more keywords
Intrinsic heterogeneity in axon regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220624
Abstract: The nervous system is composed of a variety of neurons and glial cells with different morphology and functions. In the mammalian peripheral nervous system (PNS) or the lower vertebrate central nervous system (CNS), most neurons… read more here.
Keywords: regeneration; heterogeneity; axon regeneration; heterogeneity axon ... See more keywords