Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of Chemotherapy-Induced Peripheral Neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02755-w
Abstract: Chemotherapy-Induced Peripheral Neurotoxicity (CIPN) is a severe and long-lasting side effect of anticancer therapy, which can severely impair patients’ quality of life. It is a sensory and length-dependent neuropathy, which predominantly affects large myelinated fibers.… read more here.
Keywords: axonal damage; severity; neurotoxicity; peripheral neurotoxicity ... See more keywords
Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00488-z
Abstract: Oxidative stress is a pathophysiological hallmark of many CNS diseases, among multiple sclerosis (MS). Accordingly, boosting the astrocytic transcription factor nuclear factor E2-related factor 2 (Nrf2) system in an MS mouse model efficiently ameliorates oligodendrocyte… read more here.
Keywords: axonal damage; cuprizone; neuroinflammation; model ... See more keywords
Sinomenine Alleviates Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis through Inhibiting NLRP3 Inflammasome
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DOI: 10.1007/s12031-020-01637-1
Abstract: Multiple sclerosis (MS) is known as a chronic neuroinflammatory disorder typified by an immune-mediated demyelination process with ensuing axonal damage and loss. Sinomenine is a natural alkaloid with different therapeutic benefits, including anti-inflammatory and immunosuppressive… read more here.
Keywords: sclerosis; axonal damage; model; multiple sclerosis ... See more keywords
Biological aspects of axonal damage in glaucoma: A brief review.
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DOI: 10.1016/j.exer.2017.02.006
Abstract: Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence derived from experimental studies in primates and rodents strongly indicates that the site of IOP-induced axonal damage in glaucoma is at… read more here.
Keywords: iop induced; axonal damage; damage glaucoma; glaucoma ... See more keywords
Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy
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DOI: 10.1111/jns.12319
Abstract: Axonal damage in chronic inflammatory demyelinating polyneuropathy (CIDP) is the main predictor of poor outcome. We hypothesized that serum neurofilament light chain (sNfL) reflects disease activity by detecting ongoing neuro‐axonal damage in CIDP. Three prospective… read more here.
Keywords: inflammatory demyelinating; axonal damage; demyelinating polyneuropathy; treatment ... See more keywords
Myelin and Axonal Damage in Normal-Appearing White Matter in Patients with Moyamoya Disease
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DOI: 10.3174/ajnr.a6708
Abstract: Eighteen patients with Moyamoya disease (16–55 years of age) and 18 age- and sex-matched healthy controls were evaluated with myelin-sensitive MR imaging based on magnetization transfer saturation imaging and 2-shell diffusion MR imaging. The myelin… read more here.
Keywords: patients moyamoya; axonal damage; volume; moyamoya disease ... See more keywords