Quantitative muscle ultrasound is useful for evaluating secondary axonal degeneration in chronic inflammatory demyelinating polyneuropathy
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Behavior"
DOI: 10.1002/brb3.812
Abstract: In chronic inflammatory demyelinating polyneuropathy (CIDP), exclusion of secondary axonal degeneration is challenging with conventional methods such as nerve conduction study (NCS), needle electromyography, and nerve biopsy. Increased echo intensity (EI) and decreased muscle thickness… read more here.
Keywords: inflammatory demyelinating; muscle; chronic inflammatory; axonal degeneration ... See more keywords
Neurotoxicity of the Cyanotoxin BMAA Through Axonal Degeneration and Intercellular Spreading
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9790-1
Abstract: Abstractβ-Methylamino-l-alanine (BMAA) is implicated in neurodegeneration and neurotoxicity, particularly in ALS-Parkinson Dementia Complex. Neurotoxic properties of BMAA have been partly elucidated, while its transcellular spreading capacity has not been examined. Using reconstructed neuronal networks in… read more here.
Keywords: bmaa axonal; axonal degeneration; neurotoxicity; cyanotoxin ... See more keywords
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon
Sign Up to like & getrecommendations! Published in 2021 at "Protein & Cell"
DOI: 10.1007/s13238-021-00835-w
Abstract: Axonal degeneration is one of the key features of neurodegenerative disorders. In the canonical view, axonal degeneration destructs neural connections and promotes detrimental disease defects. Here, we assessed the enteric nervous system (ENS) of the… read more here.
Keywords: sarm1; inflammation; colon; neurodegeneration ... See more keywords
Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.11.017
Abstract: Extensive pathological evidence indicates that axonal degeneration represents an early and critical event in amyotrophic lateral sclerosis (ALS). Unfortunately, few MRI studies have focused in the early detection of white matter (WM) alterations in the… read more here.
Keywords: cord; tensor imaging; axonal degeneration; diffusion tensor ... See more keywords
P345 Another brick in the wall: Is hexane neuropathy a ‘nodo-paranodopathy’?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2017.07.353
Abstract: Objectives To discuss electrophysiological follow-up of patients with n-hexane neuropathy and to remark overlaps with new concept nodo-paranodopathy. Methods 3 males, aged between 18–39 years, working in shoe manufactory were evaluated. Occupational history, toxic substance exposures,… read more here.
Keywords: hexane neuropathy; axonal degeneration; nodo paranodopathy; p345 another ... See more keywords
Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in drosophila using the automated axon quantification system, MeDUsA.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac307
Abstract: Drosophila is an excellent model organism for studying human neurodegenerative diseases (NDs). However, there is still almost no experimental system which could directly observe the degeneration of neurons and automatically quantify axonal degeneration. In this… read more here.
Keywords: system; quantification; degeneration; axonal degeneration ... See more keywords
Prevention of Axonal Degeneration by Perineurium Injection of Mitochondria in a Sciatic Nerve Crush Injury Model
Sign Up to like & getrecommendations! Published in 2017 at "Neurosurgery"
DOI: 10.1093/neuros/nyw090
Abstract: Background Axon degeneration leads to cytoskeletal disassembly, metabolism imbalance, and mitochondrial dysfunction during neurodegeneration or nerve injury. Objective In this study, we assess the possibility of mitigating axon degeneration by local injection of mitochondria in… read more here.
Keywords: injection mitochondria; axonal degeneration; injection; nerve ... See more keywords
Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12682
Abstract: Sirtuin 2 (SIRT2) is a member of a family of NAD+‐dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and mitochondria,… read more here.
Keywords: locomotor; energy; sirt2; associated redox ... See more keywords
Subarachnoid hemorrhage and axonal degeneration after C1‐C2 cervical centesis in 2 horses
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16716
Abstract: Abstract Ultrasound‐guided cervical centesis has gained popularity as a method for collecting cerebrospinal fluid (CSF) from standing horses. There are anecdotal reports of neck stiffness, regional swelling, sensitivity to palpation, and fever after the procedure.… read more here.
Keywords: subarachnoid hemorrhage; centesis; cervical centesis; axonal degeneration ... See more keywords
Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1622-1
Abstract: BackgroundIn multiple sclerosis (MS) and in the experimental autoimmune encephalomyelitis (EAE) model of MS, the Nav1.6 voltage-gated sodium (Nav) channel isoform has been implicated as a primary contributor to axonal degeneration. Following demyelination Nav1.6, which… read more here.
Keywords: nav1 promotes; model; multiple sclerosis; axonal degeneration ... See more keywords
Curdlan, a Microbial β-Glucan, Has Contrasting Effects on Autoimmune and Viral Models of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.805302
Abstract: Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelination and axonal degeneration in the central nervous system (CNS). Bacterial and fungal infections have been associated with the development of MS; microbial components that… read more here.
Keywords: curdlan; microbial glucan; axonal degeneration; curdlan microbial ... See more keywords