The Nogo receptor inhibits proliferation, migration and axonal extension by transcriptionally regulating WNK1 in PC12 cells
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DOI: 10.1097/wnr.0000000000000800
Abstract: Neuronal regeneration and axonal regrowth mechanisms in the injured mammalian central nervous system are largely unknown. As part of a major pathway for inhibiting axonal regeneration, activated neuronal glycosylphosphatidylinositol-anchored Nogo receptor (NgR) interacts with LINGO-1… read more here.
Keywords: proliferation migration; axonal extension; migration axonal; wnk1 ... See more keywords
Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning
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DOI: 10.1242/bio.025999
Abstract: ABSTRACT The robust axonal growth and regenerative capacities of young neurons decrease substantially with age. This developmental downregulation of axonal growth may facilitate axonal pruning and neural circuit formation but limits functional recovery following nerve… read more here.
Keywords: axonal extension; lis1 expression; developmental downregulation;