Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury
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DOI: 10.1002/glia.23091
Abstract: In response to traumatic brain injury (TBI) microglia/macrophages and astrocytes release inflammatory mediators with dual effects on secondary brain damage progression. The neurotrophic and anti‐inflammatory glycoprotein progranulin (PGRN) attenuates neuronal damage and microglia/macrophage activation in… read more here.
Keywords: axonal injury; astrogliosis; brain; mice ... See more keywords
Diffuse Axonal Injury
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DOI: 10.1007/978-3-319-98234-2_3
Abstract: M29, RH, plasterer, intoxicated with EtoH and crashed into a tree at 40 mph. At scene GCS E2 V2 M5, I+V+S, upon admission left pupil dilated to 5 mm read more here.
Keywords: axonal injury; diffuse axonal;
Early computed tomography for acute post-traumatic diffuse axonal injury: a systematic review.
Sign Up to like & getrecommendations! Published in 2020 at "Neuroradiology"
DOI: 10.1007/s00234-020-02383-2
Abstract: Diffuse axonal injury (DAI) is the rupture of multiple axons due to acceleration and deceleration forces during a closed head injury. Most traumatic brain injuries (TBI) have some degree of DAI, especially severe TBI. Computed… read more here.
Keywords: axonal injury; dai; tbi; injury ... See more keywords
Head-to-nerve analysis of electromechanical impairments of diffuse axonal injury
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-018-1086-8
Abstract: The aim was to investigate mechanical and functional failure of diffuse axonal injury (DAI) in nerve bundles following frontal head impacts, by finite element simulations. Anatomical changes following traumatic brain injury are simulated at the… read more here.
Keywords: head; diffuse axonal; axonal injury; nerve bundle ... See more keywords
MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats
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DOI: 10.1007/s11064-020-03063-6
Abstract: Increasing evidence has revealed that neuroinflammation plays a pivotal role in axonal injures. Nucleotide oligomerization domain (NOD)-like receptor protein (NLRP3) inflammasome is reported to be widely involved with the pathology of central nervous system disorders.… read more here.
Keywords: diffuse axonal; axonal injures; axonal injury; nlrp3 inflammasome ... See more keywords
Advances and Limitations of Current Epigenetic Studies Investigating Mammalian Axonal Regeneration
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DOI: 10.1007/s13311-018-0636-1
Abstract: SummaryAxonal regeneration relies on the expression of regenerative associated genes within a coordinated transcriptional programme, which is finely tuned as a result of the activation of several regenerative signalling pathways. In mammals, this chain of… read more here.
Keywords: advances limitations; limitations current; axonal injury; regeneration ... See more keywords
Profiling biomarkers of traumatic axonal injury: From mouse to man
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DOI: 10.1016/j.clineuro.2018.05.017
Abstract: Traumatic brain injury (TBI) poses a major public health problem on a global scale. Its burden results from high mortality and significant morbidity in survivors. This stems, in part, from an ongoing inadequacy in diagnostic… read more here.
Keywords: traumatic axonal; biomarkers traumatic; axonal injury; tbi ... See more keywords
Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury
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DOI: 10.1016/j.expneurol.2017.11.001
Abstract: ABSTRACT Since traumatic axonal injury (TAI) is implicated as a prominent pathology of concussion, we examined potential sex differences in axon structure and responses to TAI. Rat and human neurons were used to develop micropatterned… read more here.
Keywords: female axons; traumatic axonal; axonal injury; pathology ... See more keywords
Micromechanical analysis of brain's diffuse axonal injury.
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DOI: 10.1016/j.jbiomech.2017.09.029
Abstract: Computational models are important tools which help researchers understand traumatic brain injury (TBI). A mechanistic multi-scale numerical approach is introduced to quantify diffuse axonal injury (DAI), the most important mechanism of TBI, induced by a… read more here.
Keywords: brain diffuse; diffuse axonal; micromechanical analysis; axonal injury ... See more keywords
Effects of Campylobacter jejuni lipopolysaccharide on axonal injury in the spinal cord in rats.
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DOI: 10.1016/j.micpath.2017.03.020
Abstract: To explore the effects of Campylobacter jejuni lipopolysaccharide (Cj-LPS) on axonal injury in the spinal cord. Wistar rats were divided into the control (NC) group, model group (Cj-LPS), and LPS antibody group (Anti-LPS). Rats in… read more here.
Keywords: cord; axonal injury; group; effects campylobacter ... See more keywords
Recovery of Patients with Pure Diffuse Axonal Injury Who Remained in a Coma for 6 Hours or More.
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DOI: 10.1016/j.wneu.2017.09.101
Abstract: BACKGROUND Diffuse axonal injury (DAI) is a traumatic brain injury and one of the most common causes of unfavorable outcome and death. The aim of this study was to investigate the recovery of patients with… read more here.
Keywords: diffuse axonal; axonal injury; recovery patients; coma hours ... See more keywords