Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic Neuropathy
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43180-z
Abstract: Leber hereditary optic neuropathy (LHON) is a syndrome of subacute loss of central vision associated with mutations in mitochondrial DNA coding for components of complex I. LHON preferentially involves small axons in the temporal optic… read more here.
Keywords: propagation; leber hereditary; hereditary optic; axonal loss ... See more keywords
Theme 5 Human Cell Biology and Pathology
Sign Up to like & getrecommendations! Published in 2025 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2025.2564550
Abstract: Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease marked by the degeneration of both upper motor neurons (UMNs) and lower motor neurons (LMNs). A defining pathological feature of UMN degeneration is sclerosis of… read more here.
Keywords: pathology; degeneration; biology; umn als ... See more keywords
Prevention of axonal loss after immediate dosage titration of immunoglobulin in multifocal motor neuropathy
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Neurology"
DOI: 10.1111/ene.16305
Abstract: To evaluate whether ongoing axonal loss can be prevented in multifocal motor neuropathy (MMN) treated with immunoglobulin G (IgG), a group of patients with a median disease duration of 15.7 years (range: 8.3–37.8), treated with titrated… read more here.
Keywords: motor neuropathy; prevention axonal; axonal loss; multifocal motor ... See more keywords
Microtubule‐dependent processes precede pathological calcium influx in excitotoxin‐induced axon degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14909
Abstract: Axon degeneration and axonal loss is a feature of neurodegenerative disease and injury and occurs via programmed pathways that are distinct from cell death pathways. While the pathways of axonal loss following axon severing are… read more here.
Keywords: microtubule; increase; calcium; axonal loss ... See more keywords
Differentiating axonal loss and demyelination in chronic MS lesions: A novel approach using single streamline diffusivity analysis
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0244766
Abstract: We describe a new single-streamline based approach to analyse diffusivity within chronic MS lesions. We used the proposed method to examine diffusivity profiles in 30 patients with relapsing multiple sclerosis and observed a significant increase… read more here.
Keywords: chronic lesions; single streamline; diffusivity; axonal loss ... See more keywords
Early predictors of visual and axonal outcomes after acute optic neuritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.945034
Abstract: Background Predicting long-term visual outcomes and axonal loss following acute optic neuritis (ON) is critical for choosing treatment. Predictive models including all clinical and paraclinical measures of optic nerve dysfunction following ON are lacking. Objectives… read more here.
Keywords: axonal loss; acute optic; optic nerve; loss ... See more keywords
Diffusion Basis Spectrum Imaging Detects Axonal Loss After Transient Dexamethasone Treatment in Optic Neuritis Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.592063
Abstract: Optic neuritis is a frequent first symptom of multiple sclerosis (MS) for which corticosteroids are a widely employed treatment option. The Optic Neuritis Treatment Trial (ONTT) reported that corticosteroid treatment does not improve long-term visual… read more here.
Keywords: optic neuritis; treatment; corticosteroid treatment; axonal loss ... See more keywords