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Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic Neuropathy

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0 Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-43180-z

Abstract: Leber hereditary optic neuropathy (LHON) is a syndrome of subacute loss of central vision associated with mutations in mitochondrial DNA coding for components of complex I. LHON preferentially involves small axons in the temporal optic… read more here.

Keywords: propagation; leber hereditary; hereditary optic; axonal loss ... See more keywords

Microtubule‐dependent processes precede pathological calcium influx in excitotoxin‐induced axon degeneration

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0 Published in 2019 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.14909

Abstract: Axon degeneration and axonal loss is a feature of neurodegenerative disease and injury and occurs via programmed pathways that are distinct from cell death pathways. While the pathways of axonal loss following axon severing are… read more here.

Keywords: microtubule; increase; calcium; axonal loss ... See more keywords

Differentiating axonal loss and demyelination in chronic MS lesions: A novel approach using single streamline diffusivity analysis

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0 Published in 2021 at "PLoS ONE"

DOI: 10.1371/journal.pone.0244766

Abstract: We describe a new single-streamline based approach to analyse diffusivity within chronic MS lesions. We used the proposed method to examine diffusivity profiles in 30 patients with relapsing multiple sclerosis and observed a significant increase… read more here.

Keywords: chronic lesions; single streamline; diffusivity; axonal loss ... See more keywords

Early predictors of visual and axonal outcomes after acute optic neuritis

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1 Published in 2022 at "Frontiers in Neurology"

DOI: 10.3389/fneur.2022.945034

Abstract: Background Predicting long-term visual outcomes and axonal loss following acute optic neuritis (ON) is critical for choosing treatment. Predictive models including all clinical and paraclinical measures of optic nerve dysfunction following ON are lacking. Objectives… read more here.

Keywords: axonal loss; acute optic; optic nerve; loss ... See more keywords

Diffusion Basis Spectrum Imaging Detects Axonal Loss After Transient Dexamethasone Treatment in Optic Neuritis Mice

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1 Published in 2020 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2020.592063

Abstract: Optic neuritis is a frequent first symptom of multiple sclerosis (MS) for which corticosteroids are a widely employed treatment option. The Optic Neuritis Treatment Trial (ONTT) reported that corticosteroid treatment does not improve long-term visual… read more here.

Keywords: optic neuritis; treatment; corticosteroid treatment; axonal loss ... See more keywords